RNA-splicing ligase RtcB homolog

Details

Name
RNA-splicing ligase RtcB homolog
Kind
protein
Synonyms
  • 3'-phosphate/5'-hydroxy nucleic acid ligase
  • 6.5.1.8
  • C22orf28
Gene Name
RTCB
UniProtKB Entry
Q9Y3I0Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0009363|RNA-splicing ligase RtcB homolog
MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVG
GFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDI
NCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSL
REGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNE
YAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIAS
PEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQ
HVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMT
ETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTD
VVNTCHDAGISKKAIKLRPIAVIKG
Number of residues
505
Molecular Weight
55209.95
Theoretical pI
Not Available
GO Classification
Functions
metal ion binding / RNA ligase (ATP) activity / vinculin binding
Processes
in utero embryonic development / placenta development / tRNA splicing, via endonucleolytic cleavage and ligation
Components
cytoplasm / endoplasmic reticulum membrane / nuclear envelope / nucleoplasm / nucleus / tRNA-splicing ligase complex
General Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs
Specific Function
GTP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0021385|tRNA-splicing ligase RtcB homolog (RTCB)
ATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGG
AGGATCAAGAAGGGCTTCGTGCCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGAT
GCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGTGGTGTTGGT
GGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCAT
CGATCTATTGGGCTTCCTGATGTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCA
GCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGGTGGTGTCGGGTTTGACATC
AACTGTGGTGTCCGCTTGCTAAGAACCAATTTAGATGAAAGTGATGTCCAGCCTGTGAAG
GAGCAACTTGCCCAAGCTATGTTTGACCACATTCCTGTTGGGGTGGGGTCAAAAGGTGTC
ATCCCAATGAATGCCAAAGACTTGGAGGAGGCCTTGGAGATGGGGGTGGACTGGTCCTTA
AGAGAAGGGTATGCCTGGGCTGAAGACAAGGAGCACTGCGAGGAGTACGGAAGGATGCTG
CAGGCTGACCCCAATAAAGTTTCTGCAAGGGCGAAGAAAAGAGGCCTTCCTCAGTTGGGG
ACCCTGGGAGCAGGCAACCATTATGCAGAAATCCAGGTTGTGGATGAGATTTTCAATGAG
TATGCTGCTAAAAAAATGGGCATCGACCATAAGGGACAGGTGTGTGTGATGATCCACAGT
GGAAGCAGAGGCTTGGGCCACCAAGTAGCCACAGATGCGCTGGTAGCTATGGAGAAGGCC
ATGAAGAGAGACAAGATTATAGTCAATGATCGGCAGTTGGCTTGTGCTCGAATCGCTTCC
CCAGAGGGTCAAGACTATCTGAAGGGAATGGCAGCTGCTGGGAACTATGCCTGGGTCAAC
CGCTCTTCCATGACCTTCTTAACCCGTCAGGCTTTCGCCAAGGTCTTCAACACAACCCCT
GATGACTTGGACCTACATGTGATCTATGATGTTTCTCACAACATTGCCAAAGTGGAGCAG
CATGTGGTGGACGGAAAGGAACGGACACTGTTAGTACACAGGAAGGGATCCACCCGCGCT
TTCCCTCCTCACCATCCCCTCATTGCTGTTGATTACCAACTCACTGGACAGCCAGTGCTC
ATTGGTGGCACCATGGGAACCTGTAGTTATGTTCTTACTGGCACTGAACAGGGCATGACT
GAGACCTTTGGAACAACCTGTCATGGAGCGGGCCGTGCATTGTCCCGAGCAAAATCTCGA
CGTAATTTAGATTTCCAGGATGTCTTAGACAAATTGGCAGATATGGGAATTGCGATCCGT
GTTGCCTCACCCAAACTGGTTATGGAAGAGGCTCCTGAGTCCTATAAGAATGTGACAGAT
GTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATT
GCTGTGATCAAAGGATAG
Chromosome Location
22
Locus
22q12.3
External Identifiers
ResourceLink
UniProtKB IDQ9Y3I0
UniProtKB Entry NameRTCB_HUMAN
GeneCard IDRTCB
HGNC IDHGNC:26935
PDB ID(s)7P3B, 8BTT, 8ODO, 8ODP
KEGG IDhsa:51493
NCBI Gene ID51493
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Sucroseapproved, experimental, investigationalunknowntargetDetails