RNA-splicing ligase RTCB

BE0004442ProteinHumansRTCB

3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. It is acted on by 1 drug in DrugBank.

Gene name
RTCB
UniProtKB entry
Q9Y3I0Swiss-Prot
Cellular location
Nucleus
Residues / weight
505 residues · 55,210 Da
Also known as
3'-phosphate/5'-hydroxy nucleic acid ligase · 6.5.1.8 · C22orf28 · RNA 2',3'-cyclic phosphate and 5'-OH ligase

Resolves to

Protein
UniProtQ9Y3I0UniProt nameRTCB_HUMAN
Gene
HGNCHGNC:26935NCBI Gene51493GeneCardsRTCB
Pharmacology
KEGGhsa:51493
Structure
PDB7P3BPDB8BTTPDB8ODO
Drugs

What you can answer from here — as of June 05, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RNA-splicing ligase RTCB, how selective are they, and which programs against it are still in active trials?

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