Identification
- Generic Name
- Sucrose
- DrugBank Accession Number
- DB02772
- Background
A nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet (beta vulgaris), and other plants and used extensively as a food and a sweetener.
- Type
- Small Molecule
- Groups
- Approved, Experimental, Investigational
- Structure
Structure for Sucrose (DB02772)
- Weight
- Average: 342.2965
Monoisotopic: 342.116211546 - Chemical Formula
- C12H22O11
- Synonyms
- 1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside
- Beet sugar
- Cane sugar
- Sacarosa
- Saccharose
- Sacharose
- Sucraloxum
- Sucrose
- Table sugar
- White sugar
- External IDs
- GNE-410
- NSC-406942
- S-67F
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UTaste receptor type 1 member 2 Not Available Humans UBeta-lactamase Not Available Escherichia coli (strain K12) ULysozyme C Not Available Humans UActin, alpha skeletal muscle Not Available Humans UBeta-glucosidase Not Available Streptomyces sp. UAmylosucrase Not Available Neisseria polysaccharea UBeta-lactamase Not Available Escherichia coli UBeta-lactamase CTX-M Not Available Escherichia coli UHeme oxygenase Not Available Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) UCopper transport protein ATOX1 Not Available Humans UtRNA-splicing ligase RtcB homolog Not Available Humans UOrange carotenoid-binding protein Not Available Arthrospira maxima USucrose porin Not Available Salmonella typhimurium ULevansucrase Not Available Bacillus subtilis (strain 168) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Childrens Emetrol Cherry Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral WellSpring Pharmaceutical Corporation 2012-11-05 2012-11-01 US 
Childrens Emetrol Dye Free Grape Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral Well Spring Pharmaceutical Corporation 2013-04-21 2016-09-30 US Emetrol Cherry Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral Preferreed Pharmaceuticals Inc. 2012-04-23 Not applicable US Select Brand Anti-Nausea Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral L&R Distributors 2008-01-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Childrens Emetrol Cherry Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral WellSpring Pharmaceutical Corporation 2012-11-05 2012-11-01 US Childrens Emetrol Dye Free Grape Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral Well Spring Pharmaceutical Corporation 2013-04-21 2016-09-30 US Emetrol Cherry Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral Preferreed Pharmaceuticals Inc. 2012-04-23 Not applicable US Select Brand Anti-Nausea Sucrose (3.74 g/5mL) + Phosphoric acid (21.5 mg/5mL) Solution Oral L&R Distributors 2008-01-01 Not applicable US
Categories
- Drug Categories
- Carbohydrates
- Compounds used in a research, industrial, or household setting
- Diet, Food, and Nutrition
- Dietary Carbohydrates
- Dietary Sugars
- Disaccharides
- Flavoring Agents
- Food
- Food Additives
- Food Ingredients
- Nutritive Sweeteners
- Oligosaccharides
- Physiological Phenomena
- Polysaccharides
- Sweetening Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- O-glycosyl compounds
- Alternative Parents
- Disaccharides / C-glycosyl compounds / Ketals / Oxanes / Tetrahydrofurans / Secondary alcohols / Polyols / Oxacyclic compounds / Primary alcohols / Hydrocarbon derivatives
- Substituents
- Acetal / Alcohol / Aliphatic heteromonocyclic compound / C-glycosyl compound / Disaccharide / Hydrocarbon derivative / Ketal / O-glycosyl compound / Organoheterocyclic compound / Oxacycle
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- glycosyl glycoside (CHEBI:17992) / Disaccharides (C00089)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- C151H8M554
- CAS number
- 57-50-1
- InChI Key
- CZMRCDWAGMRECN-UGDNZRGBSA-N
- InChI
- InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
- IUPAC Name
- (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
- SMILES
- OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O
References
- Synthesis Reference
Francois B. Paul, Pierre F. Monsan, Magali M. C. Remaud, Vincent P. Pelenc, "Process for the enzymatic preparation from sucrose of a mixture of sugars having a high content of isomaltose, and products obtained." U.S. Patent US4861381, issued April, 1956.
US4861381- General References
- Ten S, Maclaren N: Insulin resistance syndrome in children. J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39. [Article]
- Aguilera AA, Diaz GH, Barcelata ML, Guerrero OA, Ros RM: Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-alpha in rats with sucrose-induced metabolic syndrome. J Nutr Biochem. 2004 Jun;15(6):350-7. [Article]
- Fukuchi S, Hamaguchi K, Seike M, Himeno K, Sakata T, Yoshimatsu H: Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats. Exp Biol Med (Maywood). 2004 Jun;229(6):486-93. [Article]
- Lombardo YB, Drago S, Chicco A, Fainstein-Day P, Gutman R, Gagliardino JJ, Gomez Dumm CL: Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas. Metabolism. 1996 Dec;45(12):1527-32. [Article]
- External Links
- Human Metabolome Database
- HMDB0000258
- KEGG Drug
- D00025
- KEGG Compound
- C00089
- PubChem Compound
- 5988
- PubChem Substance
- 46506134
- ChemSpider
- 5768
- BindingDB
- 50108105
- 10159
- ChEBI
- 17992
- ChEMBL
- CHEMBL253582
- ZINC
- ZINC000004217475
- PharmGKB
- PA451525
- RxList
- RxList Drug Page
- Wikipedia
- Sucrose
- PDB Entries
- 1a0t / 1ex2 / 1fe0 / 1fe4 / 1fee / 1gnx / 1iw0 / 1iw1 / 1jcq / 1jgi … show 255 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Placebo Effect 1 4 Completed Prevention Immunosuppression / Status;Splenectomy / Thalassemia 1 4 Completed Prevention Pneumococcal Infection / Thalassemia 1 4 Completed Prevention Tick Borne Encephalitis (TBE) 1 4 Completed Treatment Anemia 1 4 Completed Treatment Pain 3 4 Completed Treatment Procedural Pain 1 4 Recruiting Treatment Urinary Tract Infection Chronic 1 4 Terminated Treatment Pain Due to Certain Specified Procedures 2 3 Completed Prevention Tick Borne Encephalitis (TBE) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, chewable Oral Solution Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 185.5 °C PhysProp water solubility 2.1E+006 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP -3.70 HANSCH,C ET AL. (1995) Caco2 permeability -5.77 ADME Research, USCD pKa 12.6 MERCK INDEX (1996) - Predicted Properties
Property Value Source Water Solubility 824.0 mg/mL ALOGPS logP -2.6 ALOGPS logP -4.5 Chemaxon logS 0.38 ALOGPS pKa (Strongest Acidic) 11.84 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 8 Chemaxon Polar Surface Area 189.53 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 68.77 m3·mol-1 Chemaxon Polarizability 31.04 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.8682 Blood Brain Barrier + 0.7245 Caco-2 permeable - 0.8957 P-glycoprotein substrate Non-substrate 0.6386 P-glycoprotein inhibitor I Non-inhibitor 0.8721 P-glycoprotein inhibitor II Non-inhibitor 0.9402 Renal organic cation transporter Non-inhibitor 0.8146 CYP450 2C9 substrate Non-substrate 0.8747 CYP450 2D6 substrate Non-substrate 0.8561 CYP450 3A4 substrate Non-substrate 0.6536 CYP450 1A2 substrate Non-inhibitor 0.9425 CYP450 2C9 inhibitor Non-inhibitor 0.9377 CYP450 2D6 inhibitor Non-inhibitor 0.9395 CYP450 2C19 inhibitor Non-inhibitor 0.8821 CYP450 3A4 inhibitor Non-inhibitor 0.9716 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9258 Ames test Non AMES toxic 0.9132 Carcinogenicity Non-carcinogens 0.9565 Biodegradation Not ready biodegradable 0.7256 Rat acute toxicity 1.0936 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9633 hERG inhibition (predictor II) Non-inhibitor 0.883
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
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Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Taste receptor activity
- Specific Function
- Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
- Gene Name
- TAS1R2
- Uniprot ID
- Q8TE23
- Uniprot Name
- Taste receptor type 1 member 2
- Molecular Weight
- 95182.54 Da
References
- Servant G, Tachdjian C, Tang XQ, Werner S, Zhang F, Li X, Kamdar P, Petrovic G, Ditschun T, Java A, Brust P, Brune N, DuBois GE, Zoller M, Karanewsky DS: Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4746-51. doi: 10.1073/pnas.0911670107. Epub 2010 Feb 19. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Beta-lactamase activity
- Specific Function
- This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
- Gene Name
- ampC
- Uniprot ID
- P00811
- Uniprot Name
- Beta-lactamase
- Molecular Weight
- 41555.3 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Lysozyme activity
- Specific Function
- Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
- Gene Name
- LYZ
- Uniprot ID
- P61626
- Uniprot Name
- Lysozyme C
- Molecular Weight
- 16536.885 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Structural constituent of cytoskeleton
- Specific Function
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Name
- ACTA1
- Uniprot ID
- P68133
- Uniprot Name
- Actin, alpha skeletal muscle
- Molecular Weight
- 42050.67 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Streptomyces sp.
- Pharmacological action
- Unknown
- General Function
- Beta-glucosidase activity
- Specific Function
- Not Available
- Gene Name
- bgl3
- Uniprot ID
- Q59976
- Uniprot Name
- Beta-glucosidase
- Molecular Weight
- 52382.78 Da
- Kind
- Protein
- Organism
- Neisseria polysaccharea
- Pharmacological action
- Unknown
- General Function
- Cation binding
- Specific Function
- Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto th...
- Gene Name
- ams
- Uniprot ID
- Q9ZEU2
- Uniprot Name
- Amylosucrase
- Molecular Weight
- 72343.005 Da
- Kind
- Protein
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- General Function
- Beta-lactamase activity
- Specific Function
- Not Available
- Gene Name
- blaCTX-M-9a
- Uniprot ID
- Q9L5C8
- Uniprot Name
- Beta-lactamase
- Molecular Weight
- 30951.03 Da
References
- Bowden GA, Georgiou G: Folding and aggregation of beta-lactamase in the periplasmic space of Escherichia coli. J Biol Chem. 1990 Oct 5;265(28):16760-6. [Article]
- Kind
- Protein group
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Beta-lactamase activity
Components:
- Kind
- Protein
- Organism
- Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
- Gene Name
- hmuO
- Uniprot ID
- P71119
- Uniprot Name
- Heme oxygenase
- Molecular Weight
- 24115.81 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Metallochaperone activity
- Specific Function
- Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
- Gene Name
- ATOX1
- Uniprot ID
- O00244
- Uniprot Name
- Copper transport protein ATOX1
- Molecular Weight
- 7401.575 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Vinculin binding
- Specific Function
- Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into t...
- Gene Name
- RTCB
- Uniprot ID
- Q9Y3I0
- Uniprot Name
- tRNA-splicing ligase RtcB homolog
- Molecular Weight
- 55209.95 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Arthrospira maxima
- Pharmacological action
- Unknown
- General Function
- Photoreceptor activity
- Specific Function
- Acts as a blue-light photoreceptor and photo-protectant. Essential for inhibiting damaged induced by excess blue-green light via a process known as non-photochemical quenching (NPQ). Binding carote...
- Gene Name
- Not Available
- Uniprot ID
- P83689
- Uniprot Name
- Orange carotenoid-binding protein
- Molecular Weight
- 35347.29 Da
- Kind
- Protein
- Organism
- Salmonella typhimurium
- Pharmacological action
- Unknown
- General Function
- Porin activity
- Specific Function
- Porin for sucrose uptake.
- Gene Name
- scrY
- Uniprot ID
- P22340
- Uniprot Name
- Sucrose porin
- Molecular Weight
- 55466.87 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Levansucrase activity
- Specific Function
- Not Available
- Gene Name
- sacB
- Uniprot ID
- P05655
- Uniprot Name
- Levansucrase
- Molecular Weight
- 52970.73 Da
Drug created at June 13, 2005 13:24 / Updated at February 21, 2021 18:51