Inosine triphosphate pyrophosphatase

BE0004443ProteinHumansITPA

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. It is acted on by 2 drugs in DrugBank.

Gene name
ITPA
UniProtKB entry
Q9BY32Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
194 residues · 21,445 Da
Also known as
3.6.1.66 · C20orf37 · Inosine triphosphatase · ITPase · Non-canonical purine NTP pyrophosphatase

Resolves to

Protein
UniProtQ9BY32UniProt nameITPA_HUMAN
Gene
HGNCHGNC:6176NCBI Gene3704GeneCardsITPA
Pharmacology
KEGGhsa:3704
Structure
PDB2CARPDB2I5DPDB2J4E
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inosine triphosphate pyrophosphatase, how selective are they, and which programs against it are still in active trials?

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