SMAD family member 2

BE0004445ProteinHumansSMAD2

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. It is acted on by 1 drug in DrugBank.

Gene name
SMAD2
UniProtKB entry
Q15796Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
467 residues · 52,306 Da
Also known as
hMAD-2 · hSMAD2 · JV18-1 · MAD homolog 2 · Mad-related protein 2

Resolves to

Protein
UniProtQ15796UniProt nameSMAD2_HUMAN
Gene
HGNCHGNC:6768NCBI Gene4087GeneCardsSMAD2
Pharmacology
KEGGhsa:4087
Structure
PDB1DEVPDB1KHXPDB1U7V
Drugs

What you can answer from here — as of June 05, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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35GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which compounds in development act on SMAD family member 2, and which indications are they being tested in?

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