Protein arginine N-methyltransferase 3

BE0004446ProteinHumansPRMT3

Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566,... It is acted on by 2 drugs in DrugBank.

Gene name
PRMT3
UniProtKB entry
O60678Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
531 residues · 59,903 Da
Also known as
2.1.1.319 · Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 · HRMT1L3

Resolves to

Protein
UniProtO60678UniProt nameANM3_HUMAN
Gene
HGNCHGNC:30163NCBI Gene10196GeneCardsPRMT3
Pharmacology
IUPHAR/GtoPdb1254KEGGhsa:10196
Structure
PDB2FYTPDB3SMQPDB4HSG
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein arginine N-methyltransferase 3, how selective are they, and which programs against it are still in active trials?

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