Phosphoglycerate kinase 1

BE0004454ProteinHumansPGK1

Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). It is acted on by 5 drugs in DrugBank.

Gene name
PGK1
UniProtKB entry
P00558Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
417 residues · 44,614 Da
Also known as
2.7.11.1 · 2.7.2.3 · Cell migration-inducing gene 10 protein · PGKA · Primer recognition protein 2

Resolves to

Protein
UniProtP00558UniProt namePGK1_HUMAN
Gene
HGNCHGNC:8896NCBI Gene5230GeneCardsPGK1
Pharmacology
KEGGhsa:5230
Structure
PDB2WZBPDB2WZCPDB2WZD
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
12GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Phosphoglycerate kinase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In