Uridine 5'-monophosphate synthase

BE0004473ProteinHumansUMPS

Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate... It is acted on by 6 drugs in DrugBank.

Gene name
UMPS
UniProtKB entry
P11172Swiss-Prot
Residues / weight
480 residues · 52,221 Da
Also known as
UMP synthase

Resolves to

Protein
UniProtP11172UniProt nameUMPS_HUMAN
Gene
HGNCHGNC:12563NCBI Gene7372GeneCardsUMPS
Pharmacology
KEGGhsa:7372
Structure
PDB2EAWPDB2JGYPDB2P1F
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Uridine 5'-monophosphate synthase, how selective are they, and which programs against it are still in active trials?

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