Pulmonary surfactant-associated protein A1

BE0004481ProteinHumansSFTPA1

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. It is acted on by 2 drugs in DrugBank.

Gene name
SFTPA1
UniProtKB entry
Q8IWL2Swiss-Prot
Cellular location
Secreted
Residues / weight
248 residues · 26,242 Da
Also known as
35 kDa pulmonary surfactant-associated protein · Alveolar proteinosis protein · COLEC4 · Collectin-4 · PSAP

Resolves to

Protein
UniProtQ8IWL2UniProt nameSFTA1_HUMAN
Gene
HGNCHGNC:10798NCBI Gene653509GeneCardsSFTPA1
Pharmacology
KEGGhsa:653509
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pulmonary surfactant-associated protein A1, how selective are they, and which programs against it are still in active trials?

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