1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

BE0004490ProteinHumansPLCD1

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:15331768, PubMed:9188725). It is acted on by 2 drugs in DrugBank.

Gene name
PLCD1
UniProtKB entry
P51178Swiss-Prot
Cellular location
Cell membrane
Residues / weight
756 residues · 85,664 Da
Also known as
3.1.4.11 · Phosphoinositide phospholipase C-delta-1 · Phospholipase C-delta-1 · Phospholipase C-III · PLC-delta-1

Resolves to

Protein
UniProtP51178UniProt namePLCD1_HUMAN
Gene
HGNCHGNC:9060NCBI Gene5333GeneCardsPLCD1
Pharmacology
KEGGhsa:5333
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, and which indications are they being tested in?

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