Inositol-3-phosphate synthase 1

BE0004496ProteinHumansISYNA1

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). It is acted on by 3 drugs in DrugBank.

Gene name
ISYNA1
UniProtKB entry
Q9NPH2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
558 residues · 61,067 Da
Also known as
5.5.1.4 · hINO1 · hIPS · INO1 · IPS 1

Resolves to

Protein
UniProtQ9NPH2UniProt nameINO1_HUMAN
Gene
HGNCHGNC:29821NCBI Gene51477GeneCardsISYNA1
Pharmacology
KEGGhsa:51477
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inositol-3-phosphate synthase 1, how selective are they, and which programs against it are still in active trials?

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