Aconitate hydratase, mitochondrial

BE0004504ProteinHumansACO2

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. It is acted on by 6 drugs in DrugBank.

Gene name
ACO2
UniProtKB entry
Q99798Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
780 residues · 85,425 Da
Also known as
4.2.1.3 · Aconitase · Citrate hydro-lyase

Resolves to

Protein
UniProtQ99798UniProt nameACON_HUMAN
Gene
HGNCHGNC:118NCBI Gene50GeneCardsACO2
Pharmacology
KEGGhsa:50
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aconitate hydratase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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