Zinc citrate

Identification

Summary

Zinc citrate is an ingredient found in a variety of supplements and vitamins.

Generic Name

Zinc citrate

DrugBank Accession Number

DB11154

Background

Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration ¹.

Type

Small Molecule

Groups

Investigational

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Zinc citrate (DB11154)

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Weight

Average: 574.34
Monoisotopic: 569.794481

Chemical Formula

C₁₂H₁₀O₁₄Zn₃

Synonyms

• Citric acid, zinc salt
• Trizinc dicitrate

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Abciximab	The risk or severity of bleeding can be increased when Abciximab is combined with Zinc citrate.
Aceclofenac	The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Zinc citrate.
Acemetacin	The risk or severity of bleeding and hemorrhage can be increased when Zinc citrate is combined with Acemetacin.
Acenocoumarol	The risk or severity of bleeding can be increased when Acenocoumarol is combined with Zinc citrate.
Acetylsalicylic acid	Acetylsalicylic acid may increase the anticoagulant activities of Zinc citrate.
Albutrepenonacog alfa	The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Zinc citrate.
Alclofenac	The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Zinc citrate.
Aldesleukin	The risk or severity of bleeding can be increased when Zinc citrate is combined with Aldesleukin.
Alemtuzumab	The risk or severity of bleeding can be increased when Zinc citrate is combined with Alemtuzumab.
Alteplase	The risk or severity of bleeding can be increased when Alteplase is combined with Zinc citrate.

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Food Interactions

• Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
• Do not take with bran and high fiber foods. For optimal absorption, take zinc citrate at least 2 hours before or after eating high-fiber foods.
• Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Zinc citrate trihydrate	GNM26GAX7R	178326-57-3	VSJRDSLPNMGNFG-UHFFFAOYSA-H

Active Moieties

Name	Kind	UNII	CAS	InChI Key
Zinc	unknown	J41CSQ7QDS	7440-66-6	HCHKCACWOHOZIP-UHFFFAOYSA-N
Citric acid	unknown	XF417D3PSL	77-92-9	KRKNYBCHXYNGOX-UHFFFAOYSA-N
Zinc cation	ionic	13S1S8SF37	23713-49-7	PTFCDOFLOPIGGS-UHFFFAOYSA-N

Product Images

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Zinc 50 mg	Tablet	50 mg	Oral	Preferred Nutrition Inc.	2004-05-12	2005-08-04
Zinc Citrate - Cap 30mg	Capsule	30 mg	Oral	Sisu Inc.	1996-07-30	2006-07-31
Zinc Citrate Chelate Tab 50mg	Tablet	50 mg	Oral	Gahler Enterprises Ltd.	1979-12-31	2008-07-17
Zinc Citrate Tab 15mg	Tablet	15 mg	Oral	Gahler Enterprises Ltd.	1990-12-31	2008-07-17
Zinc Lozenges With Non-medicinal Echinacea	Lozenge	5 mg / loz	Oral	Holista Health (Canada) Inc.	1997-08-26	2001-08-01
Zinc Tab 15mg	Tablet	15 mg	Oral	Hall Laboratories, Ltd.	1981-12-31	2003-09-11
Zincitrate Cap 30mg	Capsule	30 mg	Oral	Professional Health Products	1997-06-01	2008-07-28

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Bio-b12	Zinc citrate (15.0 mg) + Cyanocobalamin (1000.0 mcg) + Folic acid (0.8 mg)	Capsule	Oral	Thorne Research Inc.	1997-09-09	2006-08-04
C-force	Zinc citrate (5 mg / cap) + Ascorbic acid (133.33 mg / cap) + Cyanocobalamin (35 mcg / cap) + Pyridoxine hydrochloride (10 mg / cap) + Thiamine (10 mg / cap)	Capsule	Oral	Prairie Naturals	1997-04-01	2002-06-21
Cal-mag (one To One) With Potass & Zinc	Zinc citrate (5 mg / tab) + Calcium citrate (250 mg / tab) + Magnesium oxide (250 mg / tab) + Potassium citrate (20 mg / tab)	Tablet	Oral	Gahler Enterprises Ltd.	1988-12-31	1999-01-27
Cal-mag Complete With Zinc, C and D	Zinc citrate (10 mg) + Ascorbic acid (150 mg) + Calcium citrate (250 mg) + Cholecalciferol (100 unit) + Magnesium oxide (250 mg)	Tablet	Oral	Quest Vitamins A Div Of Purity Life Health Products	1992-12-31	2009-07-14
Calcium and Mag-potass and Zinc Cap	Zinc citrate (5 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Potassium citrate (10 mg / cap)	Capsule	Oral	Gahler Enterprises Ltd.	1991-12-31	2001-07-26
Calcium-magnesium With K & Zn and Vitamin D3	Zinc citrate (5 mg) + Calcium citrate (125 mg) + Cholecalciferol (100 unit) + Magnesium oxide (125 mg) + Potassium citrate (10 mg)	Capsule	Oral	Holista Health (Canada) Inc.	1997-08-15	2002-08-06
Calcium, Magnesium, Zinc and D	Zinc citrate (10 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Vitamin D (100 unit / cap)	Capsule	Oral	Nutravite Pharmaceuticals Inc.	1999-08-03	2007-07-17
Children's Chewable Vit and Min Tab	Zinc citrate (2 mg) + Ascorbic acid (100 mg) + Beta carotene (5000 unit) + Biotin (10 mcg) + Calcium citrate (65 mg) + Cholecalciferol (400 unit) + Choline bitartrate (5 mg) + Cyanocobalamin (10 mcg) + Folic acid (.2 mg) + Inositol (5 mg) + Iron (5 mg) + Magnesium (25 mg) + Manganese (1 mg) + Nicotinamide (10 mg) + Calcium pantothenate (10 mg) + Potassium citrate (5 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (5 mg) + Thiamine hydrochloride (5 mg) + Vitamin E (25 unit)	Tablet	Oral	Gahler Enterprises Ltd.	1990-12-31	2002-09-11
Colgate Total Zx Pro-Shield Plus Sensitive	Zinc citrate trihydrate (20 mg/1g) + Potassium nitrate (50 mg/1g) + Sodium fluorophosphate (2 mg/1g)	Paste, dentifrice	Dental	Colgate-Palmolive	2013-02-01	2013-09-01
Collag-EN	Zinc citrate (5 mg) + Ascorbic acid (100 mg) + Manganese citrate (15 mg) + Vitamin E (15 unit)	Capsule	Oral	Thorne Research Inc.	1997-09-09	2006-08-04

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Dialyvite 3000	Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2004-02-01	Not applicable
Dialyvite 5000	Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2008-05-01	Not applicable
Dialyvite Supreme D	Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2010-09-08	Not applicable
Dialyvite with Zinc	Zinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2002-10-01	Not applicable
Prenatal Chelated Mineral	Zinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1)	Tablet	Oral	Usana Health Sciences, Inc.	2012-04-11	2017-12-31

Categories

Drug Categories

• Anticoagulants
• Calculi Dissolution Agent
• Copper Absorption Inhibitor
• Metal cations
• Metal divalent cations
• Zinc Compounds

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Tricarboxylic acids and derivatives

Direct Parent

Tricarboxylic acids and derivatives

Alternative Parents

Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds

Substituents

Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt

Molecular Framework

Not Available

External Descriptors

Not Available

Affected organisms

Not Available

Chemical Identifiers

UNII

K72I3DEX9B

CAS number

546-46-3

InChI Key

WGIWBXUNRXCYRA-UHFFFAOYSA-H

InChI

InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6

IUPAC Name

trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)

SMILES

[Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

References

General References

1. Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [Article]

External Links

PubChem Compound

11023

PubChem Substance

347827923

ChemSpider

10557

RxNav

236911

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Unknown Status	Treatment	Antioxidants / Men Infertility / Semen Quality	1
1	Completed	Basic Science	Healthy Subjects (HS)	1
1	Not Yet Recruiting	Treatment	Tuberculosis (TB)	1
Not Available	Completed	Treatment	Male Pattern of Hair Loss, Androgenic Alopecia	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, film coated	Oral
Tablet, effervescent	Oral
Liquid	Oral
Capsule	Oral
Paste, dentifrice	Dental
Tablet, coated	Oral
Wafer	Oral
Tablet	Oral
Lozenge	Oral
Capsule	Oral	30 mg
Tablet	Oral	50 mg
Tablet	Oral	15 mg
Lozenge	Oral	5 mg / loz

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	6.11 mg/mL	ALOGPS
logP	0.04	ALOGPS
logP	-1.3	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	3.05	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	140.62 Å2	ChemAxon
Rotatable Bond Count	10	ChemAxon
Refractivity	68.14 m3·mol-1	ChemAxon
Polarizability	14.23 Å3	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

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Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53