This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Zinc citrate is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Zinc citrate
- DrugBank Accession Number
- DB11154
- Background
Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration 1.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 574.34
Monoisotopic: 569.794481 - Chemical Formula
- C12H10O14Zn3
- Synonyms
- Citric acid, zinc salt
- Trizinc dicitrate
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding can be increased when Abciximab is combined with Zinc citrate. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Zinc citrate. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Zinc citrate is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Zinc citrate. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Zinc citrate. Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Zinc citrate. Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Zinc citrate. Aldesleukin The risk or severity of bleeding can be increased when Zinc citrate is combined with Aldesleukin. Alemtuzumab The risk or severity of bleeding can be increased when Zinc citrate is combined with Alemtuzumab. Alteplase The risk or severity of bleeding can be increased when Alteplase is combined with Zinc citrate. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
- Do not take with bran and high fiber foods. For optimal absorption, take zinc citrate at least 2 hours before or after eating high-fiber foods.
- Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Zinc citrate trihydrate GNM26GAX7R 178326-57-3 VSJRDSLPNMGNFG-UHFFFAOYSA-H - Active Moieties
Name Kind UNII CAS InChI Key Zinc unknown J41CSQ7QDS 7440-66-6 HCHKCACWOHOZIP-UHFFFAOYSA-N Citric acid unknown XF417D3PSL 77-92-9 KRKNYBCHXYNGOX-UHFFFAOYSA-N Zinc cation ionic 13S1S8SF37 23713-49-7 PTFCDOFLOPIGGS-UHFFFAOYSA-N - Product Images
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Zinc 50 mg Tablet 50 mg Oral Preferred Nutrition Inc. 2004-05-12 2005-08-04 Canada Zinc Citrate - Cap 30mg Capsule 30 mg Oral Sisu Inc. 1996-07-30 2006-07-31 Canada Zinc Citrate Chelate Tab 50mg Tablet 50 mg Oral Gahler Enterprises Ltd. 1979-12-31 2008-07-17 Canada Zinc Citrate Tab 15mg Tablet 15 mg Oral Gahler Enterprises Ltd. 1990-12-31 2008-07-17 Canada Zinc Lozenges With Non-medicinal Echinacea Lozenge 5 mg / loz Oral Holista Health (Canada) Inc. 1997-08-26 2001-08-01 Canada Zinc Tab 15mg Tablet 15 mg Oral Hall Laboratories, Ltd. 1981-12-31 2003-09-11 Canada Zincitrate Cap 30mg Capsule 30 mg Oral Professional Health Products 1997-06-01 2008-07-28 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bio-b12 Zinc citrate (15.0 mg) + Cyanocobalamin (1000.0 mcg) + Folic acid (0.8 mg) Capsule Oral Thorne Research Inc. 1997-09-09 2006-08-04 Canada C-force Zinc citrate (5 mg / cap) + Ascorbic acid (133.33 mg / cap) + Cyanocobalamin (35 mcg / cap) + Pyridoxine hydrochloride (10 mg / cap) + Thiamine (10 mg / cap) Capsule Oral Prairie Naturals 1997-04-01 2002-06-21 Canada Cal-mag (one To One) With Potass & Zinc Zinc citrate (5 mg / tab) + Calcium citrate (250 mg / tab) + Magnesium oxide (250 mg / tab) + Potassium citrate (20 mg / tab) Tablet Oral Gahler Enterprises Ltd. 1988-12-31 1999-01-27 Canada Cal-mag Complete With Zinc, C and D Zinc citrate (10 mg) + Ascorbic acid (150 mg) + Calcium citrate (250 mg) + Cholecalciferol (100 unit) + Magnesium oxide (250 mg) Tablet Oral Quest Vitamins A Div Of Purity Life Health Products 1992-12-31 2009-07-14 Canada Calcium and Mag-potass and Zinc Cap Zinc citrate (5 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Potassium citrate (10 mg / cap) Capsule Oral Gahler Enterprises Ltd. 1991-12-31 2001-07-26 Canada Calcium-magnesium With K & Zn and Vitamin D3 Zinc citrate (5 mg) + Calcium citrate (125 mg) + Cholecalciferol (100 unit) + Magnesium oxide (125 mg) + Potassium citrate (10 mg) Capsule Oral Holista Health (Canada) Inc. 1997-08-15 2002-08-06 Canada Calcium, Magnesium, Zinc and D Zinc citrate (10 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Vitamin D (100 unit / cap) Capsule Oral Nutravite Pharmaceuticals Inc. 1999-08-03 2007-07-17 Canada Children's Chewable Vit and Min Tab Zinc citrate (2 mg) + Ascorbic acid (100 mg) + Beta carotene (5000 unit) + Biotin (10 mcg) + Calcium citrate (65 mg) + Cholecalciferol (400 unit) + Choline bitartrate (5 mg) + Cyanocobalamin (10 mcg) + Folic acid (.2 mg) + Inositol (5 mg) + Iron (5 mg) + Magnesium (25 mg) + Manganese (1 mg) + Nicotinamide (10 mg) + Calcium pantothenate (10 mg) + Potassium citrate (5 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (5 mg) + Thiamine hydrochloride (5 mg) + Vitamin E (25 unit) Tablet Oral Gahler Enterprises Ltd. 1990-12-31 2002-09-11 Canada Colgate Total Zx Pro-Shield Plus Sensitive Zinc citrate trihydrate (20 mg/1g) + Potassium nitrate (50 mg/1g) + Sodium fluorophosphate (2 mg/1g) Paste, dentifrice Dental Colgate-Palmolive 2013-02-01 2013-09-01 US Collag-EN Zinc citrate (5 mg) + Ascorbic acid (100 mg) + Manganese citrate (15 mg) + Vitamin E (15 unit) Capsule Oral Thorne Research Inc. 1997-09-09 2006-08-04 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dialyvite 3000 Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2004-02-01 Not applicable US Dialyvite 5000 Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2008-05-01 Not applicable US Dialyvite Supreme D Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2010-09-08 Not applicable US Dialyvite with Zinc Zinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2002-10-01 Not applicable US Prenatal Chelated Mineral Zinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1) Tablet Oral Usana Health Sciences, Inc. 2012-04-11 2017-12-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Tricarboxylic acids and derivatives
- Direct Parent
- Tricarboxylic acids and derivatives
- Alternative Parents
- Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- K72I3DEX9B
- CAS number
- 546-46-3
- InChI Key
- WGIWBXUNRXCYRA-UHFFFAOYSA-H
- InChI
- InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
- IUPAC Name
- trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)
- SMILES
- [Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
References
- General References
- Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [Article]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Unknown Status Treatment Antioxidants / Men Infertility / Semen Quality 1 1 Completed Basic Science Healthy Subjects (HS) 1 1 Not Yet Recruiting Treatment Tuberculosis (TB) 1 Not Available Completed Treatment Male Pattern of Hair Loss, Androgenic Alopecia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Tablet, effervescent Oral Liquid Oral Capsule Oral Paste, dentifrice Dental Tablet, coated Oral Wafer Oral Tablet Oral Lozenge Oral Capsule Oral 30 mg Tablet Oral 50 mg Tablet Oral 15 mg Lozenge Oral 5 mg / loz - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.11 mg/mL ALOGPS logP 0.04 ALOGPS logP -1.3 ChemAxon logS -2 ALOGPS pKa (Strongest Acidic) 3.05 ChemAxon pKa (Strongest Basic) -4.2 ChemAxon Physiological Charge -3 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 140.62 Å2 ChemAxon Rotatable Bond Count 10 ChemAxon Refractivity 68.14 m3·mol-1 ChemAxon Polarizability 14.23 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53