This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Zinc citrate is an ingredient found in a variety of supplements and vitamins.

Generic Name
Zinc citrate
DrugBank Accession Number
DB11154
Background

Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration 1.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 574.34
Monoisotopic: 569.794481
Chemical Formula
C12H10O14Zn3
Synonyms
  • Citric acid, zinc salt
  • Trizinc dicitrate

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of bleeding can be increased when Abciximab is combined with Zinc citrate.
AceclofenacThe risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Zinc citrate.
AcemetacinThe risk or severity of bleeding and hemorrhage can be increased when Zinc citrate is combined with Acemetacin.
AcenocoumarolThe risk or severity of bleeding can be increased when Acenocoumarol is combined with Zinc citrate.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Zinc citrate.
Albutrepenonacog alfaThe therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Zinc citrate.
AlclofenacThe risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Zinc citrate.
AldesleukinThe risk or severity of bleeding can be increased when Zinc citrate is combined with Aldesleukin.
AlemtuzumabThe risk or severity of bleeding can be increased when Zinc citrate is combined with Alemtuzumab.
AlteplaseThe risk or severity of bleeding can be increased when Alteplase is combined with Zinc citrate.
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Food Interactions
  • Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
  • Do not take with bran and high fiber foods. For optimal absorption, take zinc citrate at least 2 hours before or after eating high-fiber foods.
  • Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Zinc citrate trihydrateGNM26GAX7R178326-57-3VSJRDSLPNMGNFG-UHFFFAOYSA-H
Active Moieties
NameKindUNIICASInChI Key
ZincunknownJ41CSQ7QDS7440-66-6HCHKCACWOHOZIP-UHFFFAOYSA-N
Citric acidunknownXF417D3PSL77-92-9KRKNYBCHXYNGOX-UHFFFAOYSA-N
Zinc cationionic13S1S8SF3723713-49-7PTFCDOFLOPIGGS-UHFFFAOYSA-N
Product Images
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Zinc 50 mgTablet50 mgOralPreferred Nutrition Inc.2004-05-122005-08-04Canada flag
Zinc Citrate - Cap 30mgCapsule30 mgOralSisu Inc.1996-07-302006-07-31Canada flag
Zinc Citrate Chelate Tab 50mgTablet50 mgOralGahler Enterprises Ltd.1979-12-312008-07-17Canada flag
Zinc Citrate Tab 15mgTablet15 mgOralGahler Enterprises Ltd.1990-12-312008-07-17Canada flag
Zinc Lozenges With Non-medicinal EchinaceaLozenge5 mg / lozOralHolista Health (Canada) Inc.1997-08-262001-08-01Canada flag
Zinc Tab 15mgTablet15 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada flag
Zincitrate Cap 30mgCapsule30 mgOralProfessional Health Products1997-06-012008-07-28Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Bio-b12Zinc citrate (15.0 mg) + Cyanocobalamin (1000.0 mcg) + Folic acid (0.8 mg)CapsuleOralThorne Research Inc.1997-09-092006-08-04Canada flag
C-forceZinc citrate (5 mg / cap) + Ascorbic acid (133.33 mg / cap) + Cyanocobalamin (35 mcg / cap) + Pyridoxine hydrochloride (10 mg / cap) + Thiamine (10 mg / cap)CapsuleOralPrairie Naturals1997-04-012002-06-21Canada flag
Cal-mag (one To One) With Potass & ZincZinc citrate (5 mg / tab) + Calcium citrate (250 mg / tab) + Magnesium oxide (250 mg / tab) + Potassium citrate (20 mg / tab)TabletOralGahler Enterprises Ltd.1988-12-311999-01-27Canada flag
Cal-mag Complete With Zinc, C and DZinc citrate (10 mg) + Ascorbic acid (150 mg) + Calcium citrate (250 mg) + Cholecalciferol (100 unit) + Magnesium oxide (250 mg)TabletOralQuest Vitamins A Div Of Purity Life Health Products1992-12-312009-07-14Canada flag
Calcium and Mag-potass and Zinc CapZinc citrate (5 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Potassium citrate (10 mg / cap)CapsuleOralGahler Enterprises Ltd.1991-12-312001-07-26Canada flag
Calcium-magnesium With K & Zn and Vitamin D3Zinc citrate (5 mg) + Calcium citrate (125 mg) + Cholecalciferol (100 unit) + Magnesium oxide (125 mg) + Potassium citrate (10 mg)CapsuleOralHolista Health (Canada) Inc.1997-08-152002-08-06Canada flag
Calcium, Magnesium, Zinc and DZinc citrate (10 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Vitamin D (100 unit / cap)CapsuleOralNutravite Pharmaceuticals Inc.1999-08-032007-07-17Canada flag
Children's Chewable Vit and Min TabZinc citrate (2 mg) + Ascorbic acid (100 mg) + Beta carotene (5000 unit) + Biotin (10 mcg) + Calcium citrate (65 mg) + Cholecalciferol (400 unit) + Choline bitartrate (5 mg) + Cyanocobalamin (10 mcg) + Folic acid (.2 mg) + Inositol (5 mg) + Iron (5 mg) + Magnesium (25 mg) + Manganese (1 mg) + Nicotinamide (10 mg) + Calcium pantothenate (10 mg) + Potassium citrate (5 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (5 mg) + Thiamine hydrochloride (5 mg) + Vitamin E (25 unit)TabletOralGahler Enterprises Ltd.1990-12-312002-09-11Canada flag
Colgate Total Zx Pro-Shield Plus SensitiveZinc citrate trihydrate (20 mg/1g) + Potassium nitrate (50 mg/1g) + Sodium fluorophosphate (2 mg/1g)Paste, dentifriceDentalColgate-Palmolive2013-02-012013-09-01US flag
Collag-ENZinc citrate (5 mg) + Ascorbic acid (100 mg) + Manganese citrate (15 mg) + Vitamin E (15 unit)CapsuleOralThorne Research Inc.1997-09-092006-08-04Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Dialyvite 3000Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2004-02-01Not applicableUS flag
Dialyvite 5000Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2008-05-01Not applicableUS flag
Dialyvite Supreme DZinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2010-09-08Not applicableUS flag
Dialyvite with ZincZinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2002-10-01Not applicableUS flag
Prenatal Chelated MineralZinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1)TabletOralUsana Health Sciences, Inc.2012-04-112017-12-31US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Tricarboxylic acids and derivatives
Direct Parent
Tricarboxylic acids and derivatives
Alternative Parents
Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
K72I3DEX9B
CAS number
546-46-3
InChI Key
WGIWBXUNRXCYRA-UHFFFAOYSA-H
InChI
InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
IUPAC Name
trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)
SMILES
[Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

References

General References
  1. Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [Article]
PubChem Compound
11023
PubChem Substance
347827923
ChemSpider
10557
RxNav
236911

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Unknown StatusTreatmentAntioxidants / Men Infertility / Semen Quality1
1CompletedBasic ScienceHealthy Subjects (HS)1
1Not Yet RecruitingTreatmentTuberculosis (TB)1
Not AvailableCompletedTreatmentMale Pattern of Hair Loss, Androgenic Alopecia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, film coatedOral
Tablet, effervescentOral
LiquidOral
CapsuleOral
Paste, dentifriceDental
Tablet, coatedOral
WaferOral
TabletOral
LozengeOral
CapsuleOral30 mg
TabletOral50 mg
TabletOral15 mg
LozengeOral5 mg / loz
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility6.11 mg/mLALOGPS
logP0.04ALOGPS
logP-1.3ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)3.05ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area140.62 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity68.14 m3·mol-1ChemAxon
Polarizability14.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53