Zinc citrate
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Zinc citrate
- Accession Number
- DB11154
- Description
Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration 1.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Zinc citrate (DB11154)
- Weight
- Average: 574.34
Monoisotopic: 569.794481 - Chemical Formula
- C12H10O14Zn3
- Synonyms
- Citric acid, zinc salt
- Trizinc dicitrate
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbciximab The risk or severity of bleeding can be increased when Abciximab is combined with Zinc citrate. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Zinc citrate. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Acemetacin is combined with Zinc citrate. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Zinc citrate. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Zinc citrate. Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Zinc citrate. Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Zinc citrate. Aldesleukin The risk or severity of bleeding can be increased when Zinc citrate is combined with Aldesleukin. Alemtuzumab The risk or severity of bleeding can be increased when Zinc citrate is combined with Alemtuzumab. Alteplase The risk or severity of bleeding can be increased when Alteplase is combined with Zinc citrate. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
- Do not take with bran and high fiber foods. For optimal absorption, take zinc citrate at least 2 hours before or after eating high-fiber foods.
- Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.
Products
- Product Ingredients
Ingredient UNII CAS InChI Key Zinc citrate trihydrate GNM26GAX7R 178326-57-3 VSJRDSLPNMGNFG-UHFFFAOYSA-H - Active Moieties
Name Kind UNII CAS InChI Key Zinc unknown J41CSQ7QDS 7440-66-6 HCHKCACWOHOZIP-UHFFFAOYSA-N Citric acid unknown XF417D3PSL 77-92-9 KRKNYBCHXYNGOX-UHFFFAOYSA-N Zinc cation ionic 13S1S8SF37 23713-49-7 PTFCDOFLOPIGGS-UHFFFAOYSA-N - Product Images
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Colgate Total Zx Pro-Shield Plus Sensitive Zinc citrate trihydrate (20 mg/1g) + Potassium nitrate (50 mg/1g) + Sodium fluorophosphate (2 mg/1g) Paste, dentifrice Dental Colgate-Palmolive 2013-02-01 2013-09-01 US 
Palm Springs Multvit and Min Tab Zinc citrate (1.25 mg) + Ascorbic acid (10 mg) + Biotin (50 mcg) + Calcium carbonate (133.4 mg) + Cholecalciferol (33.4 unit) + Chromic chloride (8.4 mcg) + Cyanocobalamin (1 mcg) + DL-alpha tocopheryl acetate (5 unit) + Ferrous fumarate (1.5 mg) + Folic acid (.0667 mg) + Nicotinamide (3.4 mg) + Calcium pantothenate (1.7 mg) + Potassium Iodide (8.3 mcg) + Pyridoxine hydrochloride (.34 mg) + Riboflavin (.29 mg) + Thiamine mononitrate (.25 mg) + Vitamin A acetate (417 unit) Tablet Oral L & S Research Corporation 1993-12-31 1996-09-09 Canada 
Prenatal Chelated Mineral Zinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1) Tablet Oral Usana Health Sciences, Inc. 2012-04-11 2017-12-31 US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dialyvite 3000 Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2004-02-01 Not applicable US Dialyvite 5000 Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2008-05-01 Not applicable US Dialyvite Supreme D Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2010-09-08 Not applicable US Dialyvite with Zinc Zinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2002-10-01 Not applicable US 
Prenatal Chelated Mineral Zinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1) Tablet Oral Usana Health Sciences, Inc. 2012-04-11 2017-12-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Tricarboxylic acids and derivatives
- Direct Parent
- Tricarboxylic acids and derivatives
- Alternative Parents
- Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- K72I3DEX9B
- CAS number
- 546-46-3
- InChI Key
- WGIWBXUNRXCYRA-UHFFFAOYSA-H
- InChI
- InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
- IUPAC Name
- trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)
- SMILES
- [Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
References
- General References
- Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [PubMed:24259556]
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Paste, dentifrice Dental Tablet, coated Oral Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.11 mg/mL ALOGPS logP 0.04 ALOGPS logP -1.3 ChemAxon logS -2 ALOGPS pKa (Strongest Acidic) 3.05 ChemAxon pKa (Strongest Basic) -4.2 ChemAxon Physiological Charge -3 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 140.62 Å2 ChemAxon Rotatable Bond Count 10 ChemAxon Refractivity 68.14 m3·mol-1 ChemAxon Polarizability 14.23 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on December 03, 2015 09:51 / Updated on June 12, 2020 10:53
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