Disks large homolog 4

BE0004524ProteinHumansDLG4

Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. It is acted on by 4 drugs in DrugBank.

Gene name
DLG4
UniProtKB entry
P78352Swiss-Prot
Cellular location
Cell membrane
Residues / weight
724 residues · 80,495 Da
Also known as
Postsynaptic density protein 95 · PSD-95 · PSD95 · SAP-90 · SAP90

Resolves to

Protein
UniProtP78352UniProt nameDLG4_HUMAN
Gene
HGNCHGNC:2903NCBI Gene1742GeneCardsDLG4
Pharmacology
KEGGhsa:1742
Structure
PDB1KEFPDB2MESPDB3I4W
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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49GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Disks large homolog 4, how selective are they, and which programs against it are still in active trials?

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