Isocitrate dehydrogenase [NADP], mitochondrial
Details
- Name
- Isocitrate dehydrogenase [NADP], mitochondrial
- Kind
- protein
- Synonyms
- 1.1.1.42
- ICD-M
- IDH
- IDP
- NADP(+)-specific ICDH
- Oxalosuccinate decarboxylase
- Gene Name
- IDH2
- UniProtKB Entry
- P48735Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0009448|Isocitrate dehydrogenase [NADP], mitochondrial MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
- Number of residues
- 452
- Molecular Weight
- 50908.915
- Theoretical pI
- Not Available
- GO Classification
- ProcessesNADP metabolic processComponentscytosol / peroxisome
- General Function
- Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)
- Specific Function
- isocitrate dehydrogenase (NADP+) activity
- Pfam Domain Function
- Iso_dh (PF00180)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0020777|Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) ATGGATGGTGATGAGATGACCCGTATTATCTGGCAGTTCATCAAGGAGAAGCTCATCCTG CCCCACGTGGACATCCAGCTAAAGTATTTTGACCTCGGGCTCCCAAACCGTGACCAGACT GATGACCAGGTCACCATTGACTCTGCACTGGCCACCCAGAAGTACAGTGTGGCTGTCAAG TGTGCCACCATCACCCCTGATGAGGCCCGTGTGGAAGAGTTCAAGCTGAAGAAGATGTGG AAAAGTCCCAATGGAACTATCCGGAACATCCTGGGGGGGACTGTCTTCCGGGAGCCCATC ATCTGCAAAAACATCCCACGCCTAGTCCCTGGCTGGACCAAGCCCATCACCATTGGCAGG CACGCCCATGGCGACCAGTACAAGGCCACAGACTTTGTGGCAGACCGGGCCGGCACTTTC AAAATGGTCTTCACCCCAAAAGATGGCAGTGGTGTCAAGGAGTGGGAAGTGTACAACTTC CCCGCAGGCGGCGTGGGCATGGGCATGTACAACACCGACGAGTCCATCTCAGGTTTTGCG CACAGCTGCTTCCAGTATGCCATCCAGAAGAAATGGCCGCTGTACATGAGCACCAAGAAC ACCATACTGAAAGCCTACGATGGGCGTTTCAAGGACATCTTCCAGGAGATCTTTGACAAG CACTATAAGACCGACTTCGACAAGAATAAGATCTGGTATGAGCACCGGCTCATTGATGAC ATGGTGGCTCAGGTCCTCAAGTCTTCGGGTGGCTTTGTGTGGGCCTGCAAGAACTATGAC GGAGATGTGCAGTCAGACATCCTGGCCCAGGGCTTTGGCTCCCTTGGCCTGATGACGTCC GTCCTGGTCTGCCCTGATGGGAAGACGATTGAGGCTGAGGCCGCTCATGGGACCGTCACC CGCCACTATCGGGAGCACCAGAAGGGCCGGCCCACCAGCACCAACCCCATCGCCAGCATC TTTGCCTGGACACGTGGCCTGGAGCACCGGGGGAAGCTGGATGGGAACCAAGACCTCATC AGGTTTGCCCAGATGCTGGAGAAGGTGTGCGTGGAGACGGTGGAGAGTGGAGCCATGACC AAGGACCTGGCGGGCTGCATTCACGGCCTCAGCAATGTGAAGCTGAACGAGCACTTCCTG AACACCACGGACTTCCTCGACACCATCAAGAGCAACCTGGACAGAGCCCTGGGCAGGCAG TAG
- Chromosome Location
- 15
- Locus
- 15q26.1
- External Identifiers
Resource Link UniProtKB ID P48735 UniProtKB Entry Name IDHP_HUMAN GeneCard ID IDH2 HGNC ID HGNC:5383 PDB ID(s) 4JA8, 5GIS, 5I95, 5I96, 5SVN, 5SVO, 6ADI, 6UJ7, 6UJ8, 6UJ9, 6VFZ KEGG ID hsa:3418 IUPHAR/Guide To Pharmacology ID 2885 NCBI Gene ID 3418 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Isocitric Acid experimental unknown target Details Enasidenib approved, investigational yes target inhibitor Details Vorasidenib approved, investigational yes target inhibitor Details