Isocitrate dehydrogenase [NADP], mitochondrial

BE0004527ProteinHumansIDH2

Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It is acted on by 5 drugs in DrugBank.

Gene name
IDH2
UniProtKB entry
P48735Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
452 residues · 50,909 Da
Also known as
1.1.1.42 · ICD-M · IDH · IDP · NADP(+)-specific ICDH

Resolves to

Protein
UniProtP48735UniProt nameIDHP_HUMAN
Gene
HGNCHGNC:5383NCBI Gene3418GeneCardsIDH2
Pharmacology
IUPHAR/GtoPdb2885KEGGhsa:3418
Structure
PDB4JA8PDB5GISPDB5I95
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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32Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isocitrate dehydrogenase [NADP], mitochondrial, how selective are they, and which programs against it are still in active trials?

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