Fumarylacetoacetase

BE0004531ProteinHumansFAH

Catalyzes the final step in the breakdown of the amino acid tyrosine, converting fumarylacetoacetate into fumarate and acetoacetate. It is acted on by 3 drugs in DrugBank.

Gene name
FAH
UniProtKB entry
P16930Swiss-Prot
Residues / weight
419 residues · 46,374 Da
Also known as
3.7.1.2 · Beta-diketonase · FAA · Fumarylacetoacetate hydrolase

Resolves to

Protein
UniProtP16930UniProt nameFAAA_HUMAN
Gene
HGNCHGNC:3579NCBI Gene2184GeneCardsFAH
Pharmacology
KEGGhsa:2184
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fumarylacetoacetase, and which indications are they being tested in?

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