ADP-ribosylation factor-like protein 1
Details
- Name
- ADP-ribosylation factor-like protein 1
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- ARL1
- UniProtKB Entry
- P40616Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0009456|ADP-ribosylation factor-like protein 1 MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKN LKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAI LVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSR Q
- Number of residues
- 181
- Molecular Weight
- 20417.36
- Theoretical pI
- Not Available
- GO Classification
- Functionsphospholipase D activator activityProcessesintracellular protein transport / vesicle-mediated transportComponentscytosol / trans-Golgi network membrane
- General Function
- GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:21239483, PubMed:22679020, PubMed:27373159, PubMed:27436755, PubMed:9624189). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988)
- Specific Function
- enzyme activator activity
- Pfam Domain Function
- Arf (PF00025)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Golgi apparatus membrane
- Gene sequence
>lcl|BSEQ0019587|ADP-ribosylation factor-like protein 1 (ARL1) ATGGGTGGCTTTTTCTCAAGTATATTTTCCAGTCTGTTTGGAACTCGGGAAATGAGAATT TTAATTTTGGGATTAGATGGAGCAGGAAAAACCACAATTTTGTACAGATTACAAGTGGGA GAAGTTGTTACTACTATACCTACCATTGGATTTAATGTAGAGACGGTGACGTACAAAAAC CTTAAATTCCAAGTCTGGGATTTAGGAGGACAGACAAGTATCAGGCCATACTGGAGATGT TACTATTCAAACACAGATGCAGTCATTTATGTAGTAGACAGTTGTGACCGAGACCGAATT GGCATTTCCAAATCAGAGTTAGTTGCCATGTTGGAGGAAGAAGAGCTGAGAAAAGCCATT TTAGTGGTGTTTGCAAATAAACAGGACATGGAACAGGCCATGACTTCCTCAGAGATGGCA AATTCACTTGGGTTACCTGCCTTGAAGGACCGAAAATGGCAGATATTCAAAACGTCAGCA ACCAAAGGCACCGGCCTTGATGAGGCAATGGAATGGTTAGTTGAAACATTAAAAAGCAGA CAGTAA
- Chromosome Location
- 12
- Locus
- 12q23.2
- External Identifiers
Resource Link UniProtKB ID P40616 UniProtKB Entry Name ARL1_HUMAN GeneCard ID ARL1 HGNC ID HGNC:692 PDB ID(s) 1UPT, 4DCN, 5EE5, 5J5C KEGG ID hsa:400 NCBI Gene ID 400 - General References
- Zhang GF, Patton WA, Lee FJ, Liyanage M, Han JS, Rhee SG, Moss J, Vaughan M: Different ARF domains are required for the activation of cholera toxin and phospholipase D. J Biol Chem. 1995 Jan 6;270(1):21-4. [Article]
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- Hong JX, Lee FJ, Patton WA, Lin CY, Moss J, Vaughan M: Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998 Jun 19;273(25):15872-6. [Article]
- Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. J Biol Chem. 2001 Jun 22;276(25):22826-37. Epub 2001 Apr 12. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Guanosine-5'-Diphosphate experimental unknown target Details