Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

BE0004551ProteinHumansCTDSP1

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. It is acted on by 2 drugs in DrugBank.

Gene name
CTDSP1
UniProtKB entry
Q9GZU7Swiss-Prot
Cellular location
Nucleus
Residues / weight
261 residues · 29,203 Da
Also known as
3.1.3.16 · NIF3 · NLI-IF · NLI-interacting factor 3 · NLIIF

Resolves to

Protein
UniProtQ9GZU7UniProt nameCTDS1_HUMAN
Gene
HGNCHGNC:21614NCBI Gene58190GeneCardsCTDSP1
Pharmacology
KEGGhsa:58190
Structure
PDB1T9ZPDB1TA0PDB2GHQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, how selective are they, and which programs against it are still in active trials?

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