T-complex protein 1 subunit gamma

BE0004554ProteinHumansCCT3

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). It is acted on by 2 drugs in DrugBank.

Gene name
CCT3
UniProtKB entry
P49368Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
545 residues · 60,533 Da
Also known as
3.6.1.- · CCT-gamma · CCTG · Chaperonin containing T-complex polypeptide 1 subunit 3 · hTRiC5

Resolves to

Protein
UniProtP49368UniProt nameTCPG_HUMAN
Gene
HGNCHGNC:1616NCBI Gene7203GeneCardsCCT3
Pharmacology
KEGGhsa:7203
Structure
PDB6NR8PDB6NR9PDB6NRA
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-complex protein 1 subunit gamma, how selective are they, and which programs against it are still in active trials?

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