Ubiquitin-like modifier-activating enzyme 1

BE0004573ProteinHumansUBA1

Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). It is acted on by 3 drugs in DrugBank.

Gene name
UBA1
UniProtKB entry
P22314Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,058 residues · 117,848 Da
Also known as
6.2.1.45 · A1S9T · Protein A1S9 · UBE1 · Ubiquitin-activating enzyme E1

Resolves to

Protein
UniProtP22314UniProt nameUBA1_HUMAN
Gene
HGNCHGNC:12469NCBI Gene7317GeneCardsUBA1
Pharmacology
KEGGhsa:7317
Structure
PDB4P22PDB6DC6PDB7PYV
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin-like modifier-activating enzyme 1, and which indications are they being tested in?

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