2-Hydroxyacid oxidase 2

BE0004577ProteinHumansHAO2

Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the corresponding 2-oxoacids (PubMed:10777549). It is acted on by 2 drugs in DrugBank.

Gene name
HAO2
UniProtKB entry
Q9NYQ3Swiss-Prot
Cellular location
Peroxisome
Residues / weight
351 residues · 38,838 Da
Also known as
(S)-2-hydroxy-acid oxidase, peroxisomal · 1.1.3.15 · Cell growth-inhibiting gene 16 protein · HAOX2 · Long chain alpha-hydroxy acid oxidase

Resolves to

Protein
UniProtQ9NYQ3UniProt nameHAOX2_HUMAN
Gene
HGNCHGNC:4810NCBI Gene51179GeneCardsHAO2
Pharmacology
KEGGhsa:51179
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-Hydroxyacid oxidase 2, how selective are they, and which programs against it are still in active trials?

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