Phosphoserine phosphatase

BE0004590ProteinHumansPSPH

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:14673469, PubMed:15291819, PubMed:25080166, PubMed:9222972). It is acted on by 5 drugs in DrugBank.

Gene name
PSPH
UniProtKB entry
P78330Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
225 residues · 25,007 Da
Also known as
3.1.3.3 · L-3-phosphoserine phosphatase · O-phosphoserine phosphohydrolase · PSP · PSPase

Resolves to

Protein
UniProtP78330UniProt nameSERB_HUMAN
Gene
HGNCHGNC:9577NCBI Gene5723GeneCardsPSPH
Pharmacology
KEGGhsa:5723
Structure
PDB1L8LPDB1L8OPDB1NNL
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphoserine phosphatase, how selective are they, and which programs against it are still in active trials?

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