GTP-binding protein Rheb

BE0004594ProteinHumansRHEB

Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141,... It is acted on by 2 drugs in DrugBank.

Gene name
RHEB
UniProtKB entry
Q15382Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
184 residues · 20,497 Da
Also known as
3.6.5.- · Ras homolog enriched in brain · RHEB2

Resolves to

Protein
UniProtQ15382UniProt nameRHEB_HUMAN
Gene
HGNCHGNC:10011NCBI Gene6009GeneCardsRHEB
Pharmacology
KEGGhsa:6009
Structure
PDB1XTQPDB1XTRPDB1XTS
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on GTP-binding protein Rheb, and which indications are they being tested in?

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