Protein arginine N-methyltransferase 1

BE0004597ProteinHumansPRMT1

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1,... It is acted on by 1 drug in DrugBank.

Gene name
PRMT1
UniProtKB entry
Q99873Swiss-Prot
Cellular location
Nucleus
Residues / weight
371 residues · 42,461 Da
Also known as
2.1.1.319 · Histone-arginine N-methyltransferase PRMT1 · HMT2 · HRMT1L2 · Interferon receptor 1-bound protein 4

Resolves to

Protein
UniProtQ99873UniProt nameANM1_HUMAN
Gene
HGNCHGNC:5187NCBI Gene3276GeneCardsPRMT1
Pharmacology
IUPHAR/GtoPdb1252KEGGhsa:3276
Structure
PDB6NT2PDB8Z2ZPDB8Z7H
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein arginine N-methyltransferase 1, and which indications are they being tested in?

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