Ribosomal protein S6 kinase alpha-4

BE0004614ProteinHumansRPS6KA4

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone... It is acted on by 1 drug in DrugBank.

Gene name
RPS6KA4
UniProtKB entry
O75676Swiss-Prot
Cellular location
Nucleus
Residues / weight
772 residues · 85,605 Da
Also known as
2.7.11.1 · 90 kDa ribosomal protein S6 kinase 4 · MSK2 · Nuclear mitogen- and stress-activated protein kinase 2 · Ribosomal protein kinase B

Resolves to

Protein
UniProtO75676UniProt nameKS6A4_HUMAN
Gene
HGNCHGNC:10433NCBI Gene8986GeneCardsRPS6KA4
Pharmacology
IUPHAR/GtoPdb1524KEGGhsa:8986
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribosomal protein S6 kinase alpha-4, how selective are they, and which programs against it are still in active trials?

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