Pyrroline-5-carboxylate reductase 3

BE0004615ProteinHumansPYCR3

Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H (PubMed:23024808, PubMed:36414121). It is acted on by 1 drug in DrugBank.

Gene name
PYCR3
UniProtKB entry
Q53H96Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
274 residues · 28,663 Da
Also known as
1.5.1.2 · P5C reductase 3 · P5CR 3 · PYCRL · Pyrroline-5-carboxylate reductase-like protein

Resolves to

Protein
UniProtQ53H96UniProt nameP5CR3_HUMAN
Gene
HGNCHGNC:25846NCBI Gene65263GeneCardsPYCR3
Pharmacology
KEGGhsa:65263
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyrroline-5-carboxylate reductase 3, how selective are they, and which programs against it are still in active trials?

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