Eukaryotic translation initiation factor 2 subunit 3

BE0004636ProteinHumansEIF2S3

Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). It is acted on by 1 drug in DrugBank.

Gene name
EIF2S3
UniProtKB entry
P41091Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
472 residues · 51,109 Da
Also known as
3.6.5.3 · eIF2-gamma X · EIF2G · eIF2gX · Eukaryotic translation initiation factor 2 subunit gamma X

Resolves to

Protein
UniProtP41091UniProt nameIF2G_HUMAN
Gene
HGNCHGNC:3267NCBI Gene1968GeneCardsEIF2S3
Pharmacology
KEGGhsa:1968
Structure
PDB6FECPDB6K71PDB6K72
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Eukaryotic translation initiation factor 2 subunit 3, and which indications are they being tested in?

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