Peroxiredoxin-6

BE0004641ProteinHumansPRDX6

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). It is acted on by 2 drugs in DrugBank.

Gene name
PRDX6
UniProtKB entry
P30041Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
224 residues · 25,035 Da
Also known as
1-Cys peroxiredoxin · 1-Cys PRX · 1.11.1.27 · 24 kDa protein · Acidic calcium-independent phospholipase A2

Resolves to

Protein
UniProtP30041UniProt namePRDX6_HUMAN
Gene
HGNCHGNC:16753NCBI Gene9588GeneCardsPRDX6
Pharmacology
KEGGhsa:9588
Structure
PDB1PRXPDB5B6MPDB5B6N
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxiredoxin-6, how selective are they, and which programs against it are still in active trials?

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