Peptidoglycan D,D-transpeptidase FtsI

BE0004647ProteinPseudomonas aeruginosapbpB

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. It is acted on by 5 drugs in DrugBank.

Gene name
pbpB
UniProtKB entry
Q51504TrEMBL
Residues / weight
579 residues · 62,856 Da
Also known as
3.4.16.4 · Cell division protein · ftsI · ftsI_1 · ftsI_2

Resolves to

Protein
UniProtQ51504UniProt nameQ51504_PSEAI
Gene
NCBI Gene881247
Pharmacology
KEGGpae:PA4418
Structure
PDB3OC2PDB3OCLPDB3OCN
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase FtsI, how selective are they, and which programs against it are still in active trials?

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