Peptidoglycan D,D-transpeptidase MrdA

BE0004648ProteinPseudomonas aeruginosapbpA

Catalyzes cross-linking of the peptidoglycan cell wall. It is acted on by 3 drugs in DrugBank.

Gene name
pbpA
UniProtKB entry
Q9X6V3TrEMBL
Residues / weight
646 residues · 72,213 Da
Also known as
3.4.16.4 · mrdA · PBP-2 · penA · Penicillin-binding protein 2

Resolves to

Protein
UniProtQ9X6V3UniProt nameQ9X6V3_PSEAI
Gene
NCBI Gene878962
Pharmacology
KEGGpae:PA4003
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase MrdA, how selective are they, and which programs against it are still in active trials?

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