Dihydropteroate synthase type-1

BE0004657ProteinEscherichia colisul1

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
sul1
UniProtKB entry
P0C002Swiss-Prot
Residues / weight
279 residues · 30,126 Da
Also known as
2.5.1.15 · DHPS · Dihydropteroate pyrophosphorylase type I · Dihydropteroate synthase type I · sul1

Resolves to

Protein
UniProtP0C002UniProt nameDHP1_ECOLX
Gene
NCBI Gene10752055
Pharmacology
KEGGpg:10752055
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Dihydropteroate synthase type-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In