Squalene epoxidase ERG1

BE0004670ProteinYeastERG1

Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:15845783, PubMed:3877503, PubMed:6378256, PubMed:9161422). It is acted on by 4 drugs in DrugBank.

Gene name
ERG1
UniProtKB entry
Q92206Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
496 residues · 55,298 Da
Also known as
1.14.14.17 · Ergosterol biosynthesis protein 1 · SE · Squalene epoxidase · Squalene monooxygenase

Resolves to

Protein
UniProtQ92206UniProt nameERG1_CANAL
Gene
NCBI Gene3646458
Pharmacology
KEGGcal:CaO19.406
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Squalene epoxidase ERG1, how selective are they, and which programs against it are still in active trials?

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