Tolnaftate is an antifungal agent used to treat various skin infections caused by fungi. Tolnaftate is a synthetic over-the-counter anti-fungal agent.
- Mechanism
- Curator reviewed
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
- Primary indication
- Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections.Curator reviewed · 7 structured indications
- Formula / weight
- C19H17NOS · 307.409 g/mol (avg)
- First approval
- Canada, 1999
- Also known as
- Tolnaphthate
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
FUSNMLFNXJSCDI-UHFFFAOYSA-NSMILESCN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1Targets
What you can answer from here — as of September 23, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Tolnaftate, and which of those have an active Phase 3 trial?
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