Coagulation factor XII

BE0004672ProteinHumansF12

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It is acted on by 10 drugs in DrugBank.

Gene name
F12
UniProtKB entry
P00748Swiss-Prot
Cellular location
Secreted
Residues / weight
615 residues · 67,792 Da
Also known as
3.4.21.38 · HAF · Hageman factor

Resolves to

Protein
UniProtP00748UniProt nameFA12_HUMAN
Gene
HGNCHGNC:3530NCBI Gene2161GeneCardsF12
Pharmacology
IUPHAR/GtoPdb2361KEGGhsa:2161
Structure
PDB4BDWPDB4BDXPDB4XDE
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor XII, how selective are they, and which programs against it are still in active trials?

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