Chromaffin granule amine transporter

BE0004674ProteinHumansSLC18A1

Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. It is acted on by 5 drugs in DrugBank.

Gene name
SLC18A1
UniProtKB entry
P54219Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle membrane
Residues / weight
525 residues · 56,257 Da
Also known as
Solute carrier family 18 member 1 · VAT1 · Vesicular amine transporter 1 · VMAT1

Resolves to

Protein
UniProtP54219UniProt nameVMAT1_HUMAN
Gene
HGNCHGNC:10934NCBI Gene6570GeneCardsSLC18A1
Pharmacology
IUPHAR/GtoPdb1011KEGGhsa:6570
Structure
PDB8TGGPDB8TGHPDB8TGI
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Chromaffin granule amine transporter, how selective are they, and which programs against it are still in active trials?

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