Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter.
- Mechanism
- Curator reviewed
Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
- Primary indication
- Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine.Curator reviewed · 4 structured indications
- Formula / weight
- C8H11NO3 · 169.1778 g/mol (avg)
- First approval
- Canada, 2010 · United States, 1982
- Also known as
- (R)-noradrenaline · (R)-norepinephrine · Arterenol · L-noradrenaline · L-Norepinephrine
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
SFLSHLFXELFNJZ-QMMMGPOBSA-NSMILESNC[C@H](O)C1=CC(O)=C(O)C=C1Targets
What you can answer from here — as of September 23, 2026
12Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
6TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Norepinephrine, and which of those have an active Phase 3 trial?
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