Electrogenic sodium bicarbonate cotransporter 1

BE0004675ProteinHumansSLC4A4

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. It is acted on by 2 drugs in DrugBank.

Gene name
SLC4A4
UniProtKB entry
Q9Y6R1Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,079 residues · 121,459 Da
Also known as
kNBC1 · Na(+)/HCO3(-) cotransporter · NBC · NBC1 · NBCE1

Resolves to

Protein
UniProtQ9Y6R1UniProt nameS4A4_HUMAN
Gene
HGNCHGNC:11030NCBI Gene8671GeneCardsSLC4A4
Pharmacology
KEGGhsa:8671
Structure
PDB6CAA
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Electrogenic sodium bicarbonate cotransporter 1, how selective are they, and which programs against it are still in active trials?

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