Sodium bicarbonate

Identification

Name
Sodium bicarbonate
Accession Number
DB01390
Description

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 84.0066
Monoisotopic: 83.982338573
Chemical Formula
CHNaO3
Synonyms
  • Baking soda
  • Bicarbonate of soda
  • Carbonic acid monosodium salt
  • NaHCO3
  • Natriumhydrogenkarbonat
  • Sodio bicarbonato
  • Sodium acid carbonate
  • Sodium bicarbonate
  • Sodium hydrogen carbonate
  • Sodium hydrogencarbonate
External IDs
  • B1654
  • E 500
  • E-500
  • E-500(II)
  • E500
  • INS NO.500(II)
  • INS-500(II)

Pharmacology

Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:
Machine Learning
Data Science
Drug Discovery
Accelerate your drug discovery research with our fully connected ADMET dataset
Learn more
Indication

Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
With our commercial data, access important information on dangerous risks, contraindications, and adverse effects.
Learn more
Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
Learn more
Pharmacodynamics

Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.

Mechanism of action

Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]

TargetActionsOrganism
AHydrogen ions
neutralizer
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
Reduce medical errors
and improve treatment outcomes with our comprehensive & structured data on drug adverse effects.
Learn more
Reduce medical errors & improve treatment outcomes with our adverse effects data
Learn more
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate.
AcetophenazineSodium bicarbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Sodium bicarbonate.
AlimemazineSodium bicarbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AllopurinolThe therapeutic efficacy of Allopurinol can be decreased when used in combination with Sodium bicarbonate.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Sodium bicarbonate.
AmprenavirSodium bicarbonate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AsunaprevirSodium bicarbonate can cause a decrease in the absorption of Asunaprevir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AtazanavirSodium bicarbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Beclomethasone dipropionateThe bioavailability of Beclomethasone dipropionate can be decreased when combined with Sodium bicarbonate.
Interactions
Improve patient outcomes
Build effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.
Learn more
Food Interactions
  • Take with or without food. Many different products contain sodium bicarbonate; refer to the product monograph for more specific instruction.

Products

Products
Comprehensive & structured drug product info
From application numbers to product codes, connect different identifiers through our commercial datasets.
Learn more
Easily connect various identifiers back to our datasets
Learn more
Active Moieties
NameKindUNIICASInChI Key
Carbon dioxideunknown142M471B3J124-38-9CURLTUGMZLYLDI-UHFFFAOYSA-N
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Bicarbonate ionionicHN1ZRA3Q2071-52-3BVKZGUZCCUSVTD-UHFFFAOYSA-M
Product Images
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
7.5% Sodium BicarbonateInjection, solution75 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-01-29Not applicableUS flag
8.4% Sodium BicarbonateInjection, solution84 mg/1mLIntravenousHF Acquisition Co. LLC, DBA HealthFirst2018-09-01Not applicableUS flag
800 Sodium Bicarbonate PowderPowder, for solutionHemodialysisBaxter Laboratories1988-12-31Not applicableCanada flag
BibagPowder, for solutionHemodialysisFresenius Medical Care Deutchland Gmbh2020-01-30Not applicableCanada flag
BibagPowder, for solutionHemodialysisFresenius Medical Care Deutchland Gmbh2009-12-10Not applicableCanada flag
Bicarb Hemodial Conc 81.25gm/lLiquidHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada flag
Bicarbolyte Bicar Hemodialysis ConcLiquidHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada flag
Bicarbonate Conc Mb-330 Pwr 650mg/pckPowderHemodialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada flag
Bicarbonate Concentrate 4105LiquidHemodialysisBaxter Laboratories1988-12-312002-08-01Canada flag
Bicarbonate Concentrate B38SolutionHemodialysisChief Medical Supplies Ltd2005-07-04Not applicableCanada flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Sodium BicarbonateInjection84 mg/1mLIntravenousMedical Purchasing Solutions, Llc2000-06-01Not applicableUS flag
Sodium BicarbonateInjection, solution84 mg/1mLIntravenousCivica2019-08-01Not applicableUS flag
Sodium BicarbonateInjection, solution75 mg/1mLIntravenousHospira, Inc.2006-05-182008-10-01US flag
Sodium BicarbonateInjection, solution42 mg/1mLIntravenousExela Pharma Sciences, LLC2019-08-01Not applicableUS flag
Sodium BicarbonateInjection, solution84 mg/1mLIntravenousExela Pharma Sciences, LLC2019-08-01Not applicableUS flag
Sodium BicarbonateInjection, solution42 mg/1mLIntravenousHospira, Inc.2020-08-26Not applicableUS flag
Sodium BicarbonateInjection84 mg/1mLIntravenousRemedy Repack2018-01-122018-03-08US flag
Sodium BicarbonateInjection, solution42 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-02-18Not applicableUS flag
Sodium BicarbonateInjection, solution75 mg/1mLIntravenousExela Pharma Sciences, LLC2019-08-01Not applicableUS flag
Sodium BicarbonateInjection84 mg/1mLIntravenousInternational Medication Systems, Limited2000-06-01Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
After Bite AdvancedLiquid50 mg/1mLTopicalAdventure Ready Brands2020-09-012023-12-31US flag
After Bite AdvancedLiquid50 mg/1mLTopicalAdventure Ready Brands2021-01-01Not applicableUS flag
After Bite KidsLiquid5 g/100gTopicalAdventure Ready Brands2020-09-01Not applicableUS flag
After Bite KidsLiquid5 g/100gTopicalTender Corporation2014-11-262020-09-30US flag
After Bite SensitiveLiquid5 g/100gTopicalTender Corporation2014-11-26Not applicableUS flag
After Bite the Itch EraserLiquid50 mg/1mLTopicalTender Corporation2014-09-022020-09-30US flag
After Bite The Itch Eraser KIDSLiquid5 g/100gTopicalTender Corporation2014-11-262014-11-26US flag
After Bite The Itch Eraser KIDSLiquid5 g/100gTopicalTender Corporation2014-11-252014-11-25US flag
After Bite WipeSwab50 mg/1mLTopicalTender Corporation2019-07-012022-09-30US flag
Anti-EmpachoLiquid525 mg/15mLOralMenper Distributors, Inc.2012-02-21Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ACIFREE® DOBLE ACCIÓNSodium bicarbonate (2.13 g) + Sodium alginate (5 g) + Calcium carbonate (3.25 g)SuspensionOral2019-12-03Not applicableColombia flag
Adea GargleSodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg)Tablet, chewableOralK2resource Co., Ltd.2018-03-01Not applicableUS flag
Adea GargleSodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg)Tablet, chewableOralK2resource Co., Ltd.2018-03-012018-04-01US flag
ALGIDROX PLUS SUSPENSION ORALSodium bicarbonate (2.67 g) + Sodium alginate (2.5 g)SuspensionOral2018-05-18Not applicableColombia flag
Alka SeltzerSodium bicarbonate (1916 mg/1) + Acetylsalicylic acid (325 mg/1) + Citric acid (1000 mg/1)Tablet, effervescentOralSalimex, S.A.2012-10-10Not applicableUS flag
Alka SeltzerSodium bicarbonate (1916 mg/1) + Acetylsalicylic acid (325 mg/1) + Citric acid (1000 mg/1)Tablet, effervescentOralSalimex, S.A.2012-10-10Not applicableUS flag
Alka Seltzer EvtSodium bicarbonate (1.916 g) + Acetylsalicylic acid (325 mg) + Citric acid (1 g)Tablet, effervescentOralMiles Inc. Pharmaceutical Division1977-12-311996-09-09Canada flag
Alka Seltzer FlavouredSodium bicarbonate (1.71 g) + Acetylsalicylic acid (325 mg) + Citric acid (1.22 g)Tablet, effervescentOralMiles Inc. Pharmaceutical Division1986-12-311996-09-09Canada flag
Alka Seltzer OriginalSodium bicarbonate (1916 mg/1) + Acetylsalicylic acid (325 mg/1) + Citric acid (1000 mg/1)Tablet, effervescentOralSavings Distributors LLC2019-07-01Not applicableUS flag
Alka Seltzer OriginalSodium bicarbonate (1916 mg/1) + Acetylsalicylic acid (325 mg/1) + Citric acid (1000 mg/1)Tablet, effervescentOralNavajo Manufacturing Company Inc.2016-09-16Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
7.5% Sodium BicarbonateSodium bicarbonate (75 mg/1mL)Injection, solutionIntravenousHF Acquisition Co LLC, DBA HealthFirst2020-01-29Not applicableUS flag
8.4% Sodium BicarbonateSodium bicarbonate (84 mg/1mL)Injection, solutionIntravenousHF Acquisition Co. LLC, DBA HealthFirst2018-09-01Not applicableUS flag
Adea GargleSodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg)Tablet, chewableOralK2resource Co., Ltd.2018-03-01Not applicableUS flag
Adea GargleSodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg)Tablet, chewableOralK2resource Co., Ltd.2018-03-012018-04-01US flag
Aqua De Folli Hair BoosterSodium bicarbonate (0.006 g/100mL) + Magnesium sulfate (0.00024 g/100mL) + Zinc sulfate, unspecified form (0.0000022 g/100mL)LiquidTopicalROKIT HEALTHCARE Inc.2020-09-24Not applicableUS flag
Aqua De Folli Hair Booster MiniSodium bicarbonate (0.006 g/100mL) + Magnesium sulfate (0.00024 g/100mL) + Zinc sulfate, unspecified form (0.0000022 g/100mL)LiquidTopicalROKIT HEALTHCARE Inc.2020-09-24Not applicableUS flag
Aqua De Folli Hair Booster ProSodium bicarbonate (0.006 g/100mL) + Magnesium sulfate (0.00024 g/100mL) + Zinc sulfate, unspecified form (0.0000022 g/100mL)LiquidTopicalROKIT HEALTHCARE Inc.2020-09-24Not applicableUS flag
Assured Bug Bite ReliefSodium bicarbonate (5 g/100g)LiquidTopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUS flag
CvsSodium bicarbonate (22.8 mg/100mg) + Sodium chloride (77.8 mg/100mg)NasalCVS PHARMACY2013-04-01Not applicableUS flag
CvsSodium bicarbonate (22.8 mg/100mg) + Sodium chloride (77.8 mg/100mg)PowderNasalCVS PHARMACY2013-06-01Not applicableUS flag

Categories

ATC Codes
B05CB04 — Sodium bicarbonateB05XA02 — Sodium bicarbonate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic salt / Organic sodium salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
one-carbon compound, organic sodium salt (CHEBI:32139)

Chemical Identifiers

UNII
8MDF5V39QO
CAS number
144-55-8
InChI Key
UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
IUPAC Name
sodium hydrogen carbonate
SMILES
[Na+].OC([O-])=O

References

Synthesis Reference

Alan B. Gancy, Rustom P. Poncha, "Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream." U.S. Patent US3984527, issued August, 1922.

US3984527
General References
  1. TITCK Product Information: ENHOŞ MEYVE TUZU (tartaric acid/sodium bicarbonate) effervescent powder [Link]
  2. INVIMA Product Authorization: Lua Plus Fruit Salt (simeticone/sodium bicarbonate) oral granules [Link]
KEGG Drug
D01203
KEGG Compound
C12603
PubChem Compound
516892
PubChem Substance
46507049
ChemSpider
8609
RxNav
36676
ChEBI
32139
ChEMBL
CHEMBL1353
Therapeutic Targets Database
DAP000128
PharmGKB
PA451375
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Sodium_bicarbonate
AHFS Codes
  • 40:08.00 — Alkalinizing Agents
  • 56:04.00 — Antacids and Adsorbents
  • 40:34.00* — Hemodialysis Solution
MSDS
Download (74 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingPreventionCatheter Complications / End Stage Renal Disease (ESRD) / Hemodialysis Access Failure / Hemodialysis Catheter Infection / Vascular Access Complications1
4Active Not RecruitingTreatmentVaricosities of the great saphenous vein1
4CompletedNot AvailableColonoscopy1
4CompletedNot AvailableNormal Healthy Subject Population1
4CompletedNot AvailablePain of Anesthesia at Breast Biopsy1
4CompletedDiagnosticAnatomic renal artery stenosis / Chronic Kidney Disease (CKD) / Pulmonary Cancer / Pulmonary Embolism1
4CompletedPreventionAcute Kidney Injury (AKI)1
4CompletedPreventionAcute Renal Failure (ARF) / End Stage Renal Disease (ESRD) / Hemodialysis Access Failure / Hemodialysis Catheter Infection / Hemodialysis Catheter-Associated Bacteremia / Hemodialysis Complication1
4CompletedPreventionContrast Induced Acute Kidney Injury1
4CompletedPreventionContrast Induced Nephropathy (CIN) / Prophylaxis of Contrast-induced nephropathy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Alaven Pharmaceutical
  • Alcon Laboratories
  • American Regent
  • Amphastar Pharmaceuticals
  • APP Pharmaceuticals
  • A-S Medication Solutions LLC
  • Atlantic Biologicals Corporation
  • B. Braun Melsungen AG
  • C.O. Truxton Inc.
  • Cardinal Health
  • Claris Lifesciences Inc.
  • Concord Labs
  • Consolidated Medical Imaging
  • Cura Pharmaceutical Co. Inc.
  • Dispensing Solutions
  • Fresenius Kabi AB
  • General Injectables and Vaccines Inc.
  • Hospira Inc.
  • Humco
  • Luitpold Pharmaceuticals Inc.
  • Mckesson Corp.
  • Mylan
  • Norwich Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Prasco Labs
  • QOL Medical
  • Sandhills Packaging Inc.
  • Santarus Inc.
Dosage Forms
FormRouteStrength
SolutionHemodialysis0.257 g/1000ml
LiquidTopical50 mg/1mL
LiquidTopical5 g/100g
SwabTopical50 mg/1mL
Tablet, effervescentOral
Injection, powder, for suspensionHemodialysis
Powder, for solutionIntraocular
CapsuleOral
LiquidTopical
LiquidTopical5 g/100mL
InjectionIntravenous
PowderOral
Powder, for solutionOral
Kit; powder, for solution; tablet, delayed releaseOral
Powder, for solutionHemodialysis
Injection, powder, for solutionHemodialysis
LiquidHemodialysis
SolutionIntravenous0.84 g
Injection, powder, lyophilized, for solutionHemodialysis
Kit; powder, for solutionHemodialysis
SolutionIntraperitoneal
Injection, solutionIntraperitoneal
Granule, effervescentOral
Granule, effervescentOral1.02 g/5g
Kit; solutionIntraocular
LiquidOphthalmic
LiquidIntravenous
SuppositoryRectal
KitIntravenous
Powder, for solutionNasogastric
SolutionHemodialysis; Topical
Solution, concentrateHemodialysis
Injection, powder, lyophilized, for solutionHemodialysis
PowderNasal
LiquidOral525 mg/15mL
SolutionParenteral
SolutionIntravenous4.21 g/1000ml
LiquidOral25 mg/1mL
Injection, solutionIntravenous
InjectionIntrathecal
GranuleHemodialysis
Tablet, delayed releaseOral
Tablet, chewableBuccal
Powder, for solutionOral1 g/1g
Powder, for solutionNasogastric; Oral
PowderTopical165 g/300g
KitOral
SolutionHemodialysis
SolutionOral
PowderOral1000 mg/1g
GranuleOral
TabletTopical60 g/100g
TabletTransmucosal
Injection
Powder, for solutionOral13.125 g
Injection, solution, concentrateOral
Injection, solutionHemodialysis; Intravenous
SolutionIntravenous
Injection, solution, concentrateParenteral
Capsule, delayed releaseOral
Kit; solutionIntraocular; Irrigation
Injection, solutionIntravenous0.2 g/5mL
TabletOral
For suspensionOral
Powder, for suspensionOral
Liquid; mouthwashOral
PasteDental
Injection, solutionIntramuscular84 mg/1mL
PowderOral
Powder, for solutionOral
KitHemodialysis
SolutionIntravenous
SolutionHemodialysis; Intravenous
SolutionHemodialysis
InjectionIntravenous
LotionTopical
KitDental
LiquidHemodialysis
LiquidOral
Granule, effervescentOral
Powder, for solutionNasal
Injection, solutionIntravenous
TabletParenteral
Injection, solution, concentrateIntravenous
Injection, solutionParenteral
InjectionIntravenous84 mg/1mL
InjectionParenteral42 mg/1mL
InjectionParenteral84 mg/1mL
Injection, solutionIntravenous1 meq/1mL
Injection, solutionIntravenous42 mg/1mL
Injection, solutionIntravenous44.6 meq/50mL
Injection, solutionIntravenous75 mg/1mL
Injection, solutionIntravenous84 mg/1mL
PowderOral; Topical100 %
SolutionIntravenous42 mg/1mL
SolutionIntravenous84 mg/1mL
SolutionParenteral84 mg/1mL
TabletOral650 mg/1
Tablet, orally disintegratingOral650 mg/1
TabletOral648 mg/1
TabletOral324 mg/1
TabletOral325 mg/1
PowderOral2.52 g/2.52g
PowderOral2.6 g/2.6g
PowderOral2.616 g/2.616g
PowderHemodialysis
LiquidIntravenous
TabletOral
PowderHemodialysis
SolutionExtracorporeal
SolutionExtracorporeal
CapsuleOral
Powder, for solutionHemodialysis
Injection, powder, for solutionIntravenous
Kit; powder, for solutionIntravenous
CreamTopical50 mg/1g
Capsule, gelatin coatedOral
Granule, for solutionOral
KitNasal
Granule, for solutionNasal
Tablet, chewableOral
SuspensionOral
Syrup
Solution
Syrup
Suspension
Tablet
Tablet, sugar coatedOral
Powder
Solution
SolutionIntravenous75 mg/1ml
Tablet
Prices
Unit descriptionCostUnit
Golytely 236 gm Solution28.0USD bottle
Colyte 240 gm Solution26.0USD bottle
Golytely 227.1 gm Solution Packet21.85USD packet
Colyte-Flavored 240 gm Solution18.17USD bottle
Elliotts b solution ampule4.71USD ml
Sodium bicarb 4.2% vial1.45USD ml
Neut 4% vial0.92USD ml
Bss plus eye solution0.2USD ml
Sodium bicarb 650 mg tablet0.07USD tablet
Antacid 650 mg tablet0.05USD tablet
Antacid 325 mg tablet0.04USD tablet
Sodium bicarb 325 mg tablet0.04USD tablet
Sodium bicarb 7.5% vial0.04USD ml
Sodium bicarbonate powder0.03USD g
Sodium bicarb 8.4% vial0.02USD ml
Sodium bicarbonate 5% inj0.02USD ml
Colyte with flavor packets0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6489346No2002-12-032016-07-16US flag
US6699885No2004-03-022016-07-16US flag
USRE45198No2014-10-142016-07-16US flag
US6645988No2003-11-112016-07-16US flag
US7399772No2008-07-152016-07-16US flag
US5945449No1999-08-312017-10-31US flag
US7300674No2007-11-272023-03-04US flag
US7291324No2007-11-062022-10-22US flag
US5840737No1998-11-242016-07-15US flag
US6780882No2004-08-242016-07-15US flag
US7084130No2006-08-012021-11-29US flag

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)Decomposes around 50 °CNot Available
water solubility1E+005 mg/L (at 25 °C)MERCK INDEX (1996)
pKa6.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility764.0 mg/mLALOGPS
logP-0.06ALOGPS
logP0.25ChemAxon
logS0.96ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity20.34 m3·mol-1ChemAxon
Polarizability3.86 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9292
Blood Brain Barrier+0.936
Caco-2 permeable-0.5321
P-glycoprotein substrateNon-substrate0.8785
P-glycoprotein inhibitor INon-inhibitor0.9903
P-glycoprotein inhibitor IINon-inhibitor0.9931
Renal organic cation transporterNon-inhibitor0.9563
CYP450 2C9 substrateNon-substrate0.8326
CYP450 2D6 substrateNon-substrate0.9017
CYP450 3A4 substrateNon-substrate0.8144
CYP450 1A2 substrateNon-inhibitor0.9053
CYP450 2C9 inhibitorNon-inhibitor0.9337
CYP450 2D6 inhibitorNon-inhibitor0.9401
CYP450 2C19 inhibitorNon-inhibitor0.9461
CYP450 3A4 inhibitorNon-inhibitor0.9774
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9911
Ames testNon AMES toxic0.9285
CarcinogenicityNon-carcinogens0.5181
BiodegradationReady biodegradable0.9636
Rat acute toxicity1.9204 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9596
hERG inhibition (predictor II)Non-inhibitor0.9866
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Targets

Drugtargets
Accelerate your drug discovery research
with our fully connected ADMET & drug target dataset.
Learn more
Accelerate your drug discovery research with our ADMET & drug target dataset
Learn more
Kind
Small molecule
Organism
Not Available
Pharmacological action
Yes
Actions
Neutralizer
References
  1. Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. [PubMed:1964114]
  2. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. [PubMed:17253467]
  3. Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. [PubMed:18154426]
  4. Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. [PubMed:12440699]
  5. Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. [PubMed:11378618]

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium:bicarbonate symporter activity
Specific Function
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate in...
Gene Name
SLC4A4
Uniprot ID
Q9Y6R1
Uniprot Name
Electrogenic sodium bicarbonate cotransporter 1
Molecular Weight
121459.38 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium:bicarbonate symporter activity
Specific Function
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. ...
Gene Name
SLC4A7
Uniprot ID
Q9Y6M7
Uniprot Name
Sodium bicarbonate cotransporter 3
Molecular Weight
136042.595 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium:bicarbonate symporter activity
Specific Function
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell ...
Gene Name
SLC4A8
Uniprot ID
Q2Y0W8
Uniprot Name
Electroneutral sodium bicarbonate exchanger 1
Molecular Weight
122936.66 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium:bicarbonate symporter activity
Specific Function
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues i...
Gene Name
SLC4A5
Uniprot ID
Q9BY07
Uniprot Name
Electrogenic sodium bicarbonate cotransporter 4
Molecular Weight
126254.04 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium:bicarbonate symporter activity
Specific Function
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).
Gene Name
SLC4A10
Uniprot ID
Q6U841
Uniprot Name
Sodium-driven chloride bicarbonate exchanger
Molecular Weight
125945.115 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220]

Drug created on July 08, 2007 16:59 / Updated on April 11, 2021 00:58