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Identification
- Summary
Sodium bicarbonate is a compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
- Brand Names
- Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
- Generic Name
- Sodium bicarbonate
- DrugBank Accession Number
- DB01390
- Background
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Sodium bicarbonate (DB01390)
- Weight
- Average: 84.0066
Monoisotopic: 83.982338573 - Chemical Formula
- CHNaO3
- Synonyms
- Baking soda
- Bicarbonate of soda
- Carbonic acid monosodium salt
- NaHCO3
- Natriumhydrogenkarbonat
- Sodio bicarbonato
- Sodium acid carbonate
- Sodium bicarbonate
- Sodium hydrogen carbonate
- Sodium hydrogencarbonate
- External IDs
- B1654
- E 500
- E-500
- E-500(II)
- E500
- INS NO.500(II)
- INS-500(II)
Pharmacology
- Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Acid indigestion ••• ••• Management of Barbiturate intoxication •••••••••••• Used in combination as diagnostic agent Breast cancer Combination Product in combination with: Tetrofosmin (DB11180) •••••••••••• ••••• •••• ••••••• ••• •••••••• Used in combination to treat Constipation Combination Product in combination with: Potassium bitartrate (DB11107) ••• ••• ••••••••••• Prophylaxis of Contrast-induced nephropathy ••• ••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
- Mechanism of action
Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
Target Actions Organism AVoltage-dependent T-type calcium channel subunit alpha-1H blockerHumans AA-type voltage-gated potassium channel KCND3 blockerHumans AHydrogen ions neutralizer- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate. Acetophenazine Sodium bicarbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Sodium bicarbonate. Alimemazine Sodium bicarbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Sodium bicarbonate. - Food Interactions
- Take with or without food. Many different products contain sodium bicarbonate; refer to the product monograph for more specific instruction.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N Carbon dioxide unknown 142M471B3J 124-38-9 CURLTUGMZLYLDI-UHFFFAOYSA-N Bicarbonate ion ionic HN1ZRA3Q20 71-52-3 BVKZGUZCCUSVTD-UHFFFAOYSA-M - Product Images
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 7.5% Sodium Bicarbonate Injection, solution 75 mg/1mL Intravenous HF Acquisition Co LLC, DBA HealthFirst 2020-01-29 Not applicable US 
8.4% Sodium Bicarbonate Injection, solution 84 mg/1mL Intravenous HF Acquisition Co. LLC, DBA HealthFirst 2018-09-01 Not applicable US 800 Sodium Bicarbonate Powder Powder, for solution 650 g / 8 L Baxter Laboratories 1988-12-31 2021-07-23 Canada 
Bibag Powder, for solution 900 g / bag Fresenius Medical Care Korea 2020-01-30 Not applicable Canada Bibag Powder, for solution 650 g / bag Fresenius Medical Care Korea 2009-12-10 Not applicable Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Sodium Bicarbonate Injection, solution 84 mg/1mL Intravenous NorthStar Rx LLC 2024-02-19 Not applicable US Sodium Bicarbonate Injection, solution 84 mg/1mL Intravenous Henry Schein, Inc. 2022-01-17 Not applicable US Sodium Bicarbonate Injection, solution 84 mg/1mL Intravenous Steriscience Specialties Private Limited 2024-03-08 Not applicable US Sodium Bicarbonate Injection, solution 84 mg/1mL Intravenous Medical Purchasing Solutions, Llc 2020-07-23 Not applicable US Sodium Bicarbonate Injection 84 mg/1mL Intravenous Remedy Repack 2018-01-12 2018-03-08 US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image After Bite Advanced Liquid 50 mg/1mL Topical Adventure Ready Brands 2021-01-01 Not applicable US After Bite Advanced Liquid 50 mg/1mL Topical Adventure Ready Brands 2020-09-01 2023-12-31 US After Bite Kids Liquid 5 g/100g Topical Adventure Ready Brands 2020-09-01 Not applicable US After Bite Kids Liquid 5 g/100g Topical Tender Corporation 2014-11-26 2020-09-30 US After Bite Sensitive Liquid 5 g/100g Topical Tender Corporation 2014-11-26 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ACCUSOL 35 Sodium bicarbonate (12.9 g/L) + Calcium chloride dihydrate (0.343 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Sodium chloride (7.66 g/L) Solution บริษัท ซิลลิค ฟาร์มา จำกัด 2015-08-31 Not applicable Thailand 
Accusol 35 Potassium 4 mmol/l Solution for Haemofiltration, Haemodialysis and Haemodiafiltration Sodium bicarbonate (13.4 g/L) + Calcium chloride dihydrate (0.343 g/L) + D-glucose monohydrate (1.47 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Potassium chloride (0.398 g/L) + Sodium chloride (7.52 g/L) Solution Extracorporeal XCORE SERVICES SDN BHD 2020-09-08 2021-12-12 Malaysia 
Accusol 35 Solution for Haemofiltration, Haemodialysis and Haemodiafiltration Sodium bicarbonate (13.4 g/L) + Calcium chloride dihydrate (0.343 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Sodium chloride (7.52 g/L) Solution Extracorporeal XCORE SERVICES SDN BHD 2020-09-08 2021-12-12 Malaysia ACIFREE® DOBLE ACCIÓN Sodium bicarbonate (2.13 g) + Sodium alginate (5 g) + Calcium carbonate (3.25 g) Suspension Oral LABORATORIOS DEMAC LTDA. 2019-12-03 Not applicable Colombia 
Adea Gargle Sodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg) Tablet, chewable Oral K2resource Co., Ltd. 2018-03-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 7.5% Sodium Bicarbonate Sodium bicarbonate (75 mg/1mL) Injection, solution Intravenous HF Acquisition Co LLC, DBA HealthFirst 2020-01-29 Not applicable US 8.4% Sodium Bicarbonate Sodium bicarbonate (84 mg/1mL) Injection, solution Intravenous HF Acquisition Co. LLC, DBA HealthFirst 2018-09-01 Not applicable US Adea Gargle Sodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg) Tablet, chewable Oral K2resource Co., Ltd. 2018-03-01 2018-04-01 US Adea Gargle Sodium bicarbonate (36.2 g/100mg) + Xylitol (5 g/100mg) Tablet, chewable Oral K2resource Co., Ltd. 2018-03-01 Not applicable US All natural Saline Packets CareOne Sodium bicarbonate (700 mg/3000mg) + Sodium chloride (2300 mg/3000mg) Powder, for solution Nasal Foodhold U.S.A. 2022-01-08 Not applicable US
Categories
- ATC Codes
- B05CB04 — Sodium bicarbonate
- B05CB — Salt solutions
- B05C — IRRIGATING SOLUTIONS
- B05 — BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
- B — BLOOD AND BLOOD FORMING ORGANS
- Drug Categories
- Antacids
- Antacids and Adsorbents
- Bicarbonates
- Blood and Blood Forming Organs
- Blood Substitutes and Perfusion Solutions
- Carbon Compounds, Inorganic
- Carbonates
- Carbonic Acid
- Electrolyte Solutions
- Gastric Acid Lowering Agents
- Hemodialysis Solution
- I.V. Solution Additives
- Irrigating Solutions
- Salt Solutions
- Sodium Compounds
- Urinary Alkalinisers
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Organic carbonic acids and derivatives
- Sub Class
- Organic carbonic acids
- Direct Parent
- Organic carbonic acids
- Alternative Parents
- Carbonate salts / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic salt / Organic sodium salt
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- one-carbon compound, organic sodium salt (CHEBI:32139)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 8MDF5V39QO
- CAS number
- 144-55-8
- InChI Key
- UIIMBOGNXHQVGW-UHFFFAOYSA-M
- InChI
- InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
- IUPAC Name
- sodium hydrogen carbonate
- SMILES
- [Na+].OC([O-])=O
References
- Synthesis Reference
Alan B. Gancy, Rustom P. Poncha, "Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream." U.S. Patent US3984527, issued August, 1922.
US3984527- General References
- TITCK Product Information: ENHOŞ MEYVE TUZU (tartaric acid/sodium bicarbonate) effervescent powder [Link]
- INVIMA Product Authorization: Lua Plus Fruit Salt (simeticone/sodium bicarbonate) oral granules [Link]
- AIFA Package Leaflet: TETROFOSMINA ROTOP (sodium bicarbonate and tetrofosmin) intravenous kit [Link]
- FDA Approved Drug Products: KONVOMEP™ (omeprazole and sodium bicarbonate for oral suspension) [Link]
- External Links
- Human Metabolome Database
- HMDB0303541
- KEGG Drug
- D01203
- KEGG Compound
- C12603
- PubChem Compound
- 516892
- PubChem Substance
- 46507049
- ChemSpider
- 8609
- 36676
- ChEBI
- 32139
- ChEMBL
- CHEMBL1353
- Therapeutic Targets Database
- DAP000128
- PharmGKB
- PA451375
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Sodium_bicarbonate
- MSDS
- Download (74 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Prevention Acute Kidney Injury (AKI) / Coronavirus Disease 2019 (COVID‑19) 1 somestatus stop reason just information to hide Not Available Completed Other Acute Kidney Injury (AKI) / Metabolic Acidosis 1 somestatus stop reason just information to hide 4 Active Not Recruiting Health Services Research Colorectal Cancer 1 somestatus stop reason just information to hide 4 Completed Not Available Colonoscopy 1 somestatus stop reason just information to hide 4 Completed Not Available Normal Healthy Subject Population 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Alaven Pharmaceutical
- Alcon Laboratories
- American Regent
- Amphastar Pharmaceuticals
- APP Pharmaceuticals
- A-S Medication Solutions LLC
- Atlantic Biologicals Corporation
- B. Braun Melsungen AG
- C.O. Truxton Inc.
- Cardinal Health
- Claris Lifesciences Inc.
- Concord Labs
- Consolidated Medical Imaging
- Cura Pharmaceutical Co. Inc.
- Dispensing Solutions
- Fresenius Kabi AB
- General Injectables and Vaccines Inc.
- Hospira Inc.
- Humco
- Luitpold Pharmaceuticals Inc.
- Mckesson Corp.
- Mylan
- Norwich Pharmaceuticals Inc.
- Physicians Total Care Inc.
- Prasco Labs
- QOL Medical
- Sandhills Packaging Inc.
- Santarus Inc.
- Dosage Forms
Form Route Strength Powder, for solution 650 g / 8 L Solution Hemodialysis 0.257 g/1000ml Liquid Topical 50 mg/1mL Liquid Topical 5 g/100g Swab Topical 50 mg/1mL Liquid Topical 50 mg/1000mL Tablet, effervescent Oral Tablet Oral 1000.000 mg Tablet Oral 324 mg Injection, powder, for suspension Hemodialysis 750 mg Powder, for solution Intraocular Liquid Topical Liquid Topical 5 g/100mL Solution Intravenous 8.4 % Injection Intravenous 5 % Solution Hemodialysis; Topical 8.4 g Cream Topical 4.5 g/90mL Powder Oral 100 % Powder, for solution Oral 100 g Granule Oral 460 mg/g Powder, for solution Hemodialysis Solution Intravenous 0.750 g Kit; powder, for solution; tablet, delayed release Oral Powder, for solution 650 g / bag Powder, for solution 900 g / bag Powder, for solution Extracorporeal 100 % Powder, for solution Hemodialysis 100 g Powder, for solution Hemodialysis 100 % Injection, powder, for solution Hemodialysis 100 g Liquid Hemodialysis 81.25 g / L Liquid Hemodialysis 72 g / L Liquid Hemodialysis 80.68 g / L Solution Hemodialysis 80.7 g / L Solution 81.3 g / L Liquid Hemodialysis Solution Intravenous 0.8401 g Solution Intravenous 840 mg Solution Intravenous 0.84 g Solution Parenteral 840 mg Injection, powder, lyophilized, for solution Hemodialysis 8.125 g Solution Intravenous 840.1 mg Powder 1250 g / cartridge Powder 720 g / cartridge Powder Hemodialysis 650 g / cartridge Powder, for solution Hemodialysis 750 g / cartridge Powder, for solution 900 g / cartridge Solution Hemodialysis; Intravenous Solution Hemodialysis; Intravenous 0.187 g/L Solution Other Granule, effervescent Oral Granule, effervescent Oral 1.02 g/5g Granule, effervescent Oral 1.8 g / 6 g Granule, effervescent Oral 269 mg / g Concentrate; kit; solution Ophthalmic Kit; solution Intraocular Liquid Ophthalmic Liquid Intravenous Suppository Rectal Kit Intravenous Powder, for solution Nasogastric Solution Hemodialysis; Topical 6.5527 g Solution, concentrate Hemodialysis Injection, powder, lyophilized, for solution Hemodialysis Kit; powder Nasal Powder Nasal Powder, for solution Hemodialysis 650 g / pck Injection Intravenous Liquid Oral 525 mg/15mL Solution Parenteral 8.4 g Solution Intravenous 3.750 g Injection Intravenous 84 mg/ml Solution Intravenous 4.21 g/1000ml Liquid Oral 25 mg/1mL Injection, solution Intravenous Solution Intravenous 750.00 mg Injection Intrathecal Injection, solution Intraperitoneal Granule, for solution Oral 64 g Granule Hemodialysis 100 g Tablet, delayed release Oral 1000 MG Suspension Oral 325 MG/10ML Tablet, chewable Oral 187.5 MG Suspension Oral 160 MG/10ML Tablet, chewable Oral 80 MG Tablet, chewable Buccal Powder, for solution Oral 1 g/1g Powder, for solution Nasogastric; Oral Powder Topical 165 g/300g Solution Hemodialysis Kit Oral Solution Hemodialysis 66 g/l Powder 6 kg / container Powder, for solution Hemodialysis 650 g / cartridge Solution, concentrate Hemodialysis 8.4 g/100mL Solution, concentrate Intravenous 8.4 g/100mL Solution Hemodialysis 8.4 g Injection, solution Intravenous 12.18 g/L Injection, solution Intravenous 12.18 g/1000ml Injection, solution Intravenous 14 g/1000ml Injection, solution Intravenous 14 g/L Injection, solution Intravenous 8.4 % Powder Oral 1000 mg/1g Granule Oral Liquid Ophthalmic; Topical Kit; solution; suspension Oral Tablet Topical 60 g/100g Tablet Transmucosal Injection Solution Intravenous 0.84 g/10ml Powder, for solution Oral 13.125 g Powder, for solution Oral 13.125 G Injection, solution, concentrate Oral Solution Intravenous 4.410 g Injection, solution Hemodialysis; Intravenous Solution Intravenous 1.68 g Injection, solution, concentrate Parenteral 8.4 % Capsule, delayed release Oral 500 mg Kit; solution Intraocular; Irrigation Capsule, delayed release Oral 840 mg Injection, solution Intravenous 0.2 g/5mL Solution Oral Tablet Oral For suspension Oral Powder, for suspension Oral Liquid; mouthwash Oral Paste Dental Injection, solution Intramuscular 84 mg/1mL Powder Oral 238.33 g Solution Intraperitoneal Powder Oral Powder, for solution Oral Suspension Oral Solution Hemodialysis; Intravenous 0.27 g/l Kit Hemodialysis Solution Intravenous Injection Intravenous Solution Hemodialysis 0.257 g/l Lotion Topical Kit Dental Liquid Oral Granule, effervescent Oral 1.415 g Powder, for solution Oral 56.6 g Powder, for solution Nasal Kit; powder, for solution Nasal Kit; powder; solution Nasal Injection, solution Intravenous Injection, solution Parenteral 1 MEQ/ML Tablet Parenteral Injection, solution Parenteral 1 MEQ/1ML Injection, solution Parenteral 1.4 % Injection, solution Parenteral 5 % Injection, solution Parenteral 7.5 % Injection, solution Parenteral 8.4 % Injection, solution Parenteral 8.4 G/100MG Injection, solution, concentrate Intravenous Injection, solution Parenteral 1 MEQ/10ML Injection, solution Parenteral Injection, solution, concentrate Intravenous 1 MEQ/ML Injection, solution, concentrate Intravenous 10 MEQ/10ML Injection Intravenous 84 mg/1mL Injection Parenteral 42 mg/1mL Injection Parenteral 84 mg/1mL Injection, solution Intravenous 1 meq/1mL Injection, solution Intravenous 42 mg/1mL Injection, solution Intravenous 44.6 meq/50mL Injection, solution Intravenous 75 mg/1mL Injection, solution Intravenous 84 mg/1mL Powder Oral; Topical 100 % Solution Intravenous 42 mg/1mL Solution Intravenous 84 mg/1mL Solution Parenteral 84 mg/1mL Tablet 500 MG Tablet Oral 650 mg/1 Tablet, orally disintegrating Oral 650 mg/1 Tablet Oral 648 mg/1 Tablet, soluble Oral 648 mg/1 Tablet Oral 325 mg/1 Tablet, soluble Oral 324 mg/1 Liquid Intravenous 50 mg / mL Solution Intravenous 5 g / 100 mL Powder Oral 2.52 g/2.52g Powder Oral 2.6 g/2.6g Powder Oral 2.616 g/2.616g Capsule Oral 500 mg Powder, for solution Hemodialysis 672 g / pck Powder Hemodialysis 650 g / pck Liquid Intravenous 42 mg / mL Liquid Intravenous 75 mg / mL Liquid Intravenous 84 mg / mL Solution Intravenous 4200 mg / 50 mL Solution Intravenous 840 mg / 10 mL Solution Intravenous 75 mg / mL Injection Intravenous 8.4 g/100ml Solution Intravenous 42 mg / mL Solution Intravenous 84 mg / mL Injection Intravenous 8.4 % w/v Injection Intravenous 4.2 % w/v Tablet Oral 300 mg Tablet Oral 600 mg Powder Hemodialysis 650 g / sachet Powder Hemodialysis Powder, for solution Hemodialysis 1100 g / cartridge Powder, for solution Hemodialysis 760 g / cartridge Solution Extracorporeal 0.42 g/L Solution Extracorporeal Solution Extracorporeal Solution Capsule Oral Injection, powder, for solution Intravenous Kit; powder, for solution Intravenous Cream Topical 50 mg/1g Capsule, gelatin coated Oral Solution 80.7 g / L Injection, solution Intravenous 840 mg/10ml Granule, effervescent Oral 0.72 g Granule, for solution Oral Tablet Oral 200 mg Tablet Oral 250 mg Kit Nasal Granule, for solution Nasal Tablet, chewable Oral Syrup Syrup 50 mg/5ml Suspension Tablet 300 mg Solution 0.6 g/5mL Tablet, sugar coated Oral Powder Solution 50 mg/5ml Tablet 650 mg Solution Intravenous 75 mg/1ml Tablet - Prices
Unit description Cost Unit Golytely 236 gm Solution 28.0USD bottle Colyte 240 gm Solution 26.0USD bottle Golytely 227.1 gm Solution Packet 21.85USD packet Colyte-Flavored 240 gm Solution 18.17USD bottle Elliotts b solution ampule 4.71USD ml Sodium bicarb 4.2% vial 1.45USD ml Neut 4% vial 0.92USD ml Bss plus eye solution 0.2USD ml Sodium bicarb 650 mg tablet 0.07USD tablet Antacid 650 mg tablet 0.05USD tablet Antacid 325 mg tablet 0.04USD tablet Sodium bicarb 325 mg tablet 0.04USD tablet Sodium bicarb 7.5% vial 0.04USD ml Sodium bicarbonate powder 0.03USD g Sodium bicarb 8.4% vial 0.02USD ml Sodium bicarbonate 5% inj 0.02USD ml Colyte with flavor packets 0.01USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6489346 No 2002-12-03 2016-07-16 US US6699885 No 2004-03-02 2016-07-16 US USRE45198 No 2014-10-14 2016-07-16 US US6645988 No 2003-11-11 2016-07-16 US US7399772 No 2008-07-15 2016-07-16 US US5945449 No 1999-08-31 2017-10-31 US US7300674 No 2007-11-27 2023-03-04 US US7291324 No 2007-11-06 2022-10-22 US US5840737 No 1998-11-24 2016-07-15 US US6780882 No 2004-08-24 2016-07-15 US US7084130 No 2006-08-01 2021-11-29 US US10751333 No 2020-08-25 2039-07-16 US US11103492 No 2021-08-31 2039-07-16 US US11633478 No 2019-07-16 2039-07-16 US US11771686 No 2020-03-01 2040-03-01 US US11911473 No 2019-07-16 2039-07-16 US US12042539 No 2019-07-16 2039-07-16 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) Decomposes around 50 °C Not Available water solubility 1E+005 mg/L (at 25 °C) MERCK INDEX (1996) pKa 6.3 Not Available - Predicted Properties
Property Value Source Water Solubility 764.0 mg/mL ALOGPS logP -0.06 ALOGPS logP 0.25 Chemaxon logS 0.96 ALOGPS pKa (Strongest Acidic) 3.5 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 60.36 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 20.34 m3·mol-1 Chemaxon Polarizability 3.86 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9292 Blood Brain Barrier + 0.936 Caco-2 permeable - 0.5321 P-glycoprotein substrate Non-substrate 0.8785 P-glycoprotein inhibitor I Non-inhibitor 0.9903 P-glycoprotein inhibitor II Non-inhibitor 0.9931 Renal organic cation transporter Non-inhibitor 0.9563 CYP450 2C9 substrate Non-substrate 0.8326 CYP450 2D6 substrate Non-substrate 0.9017 CYP450 3A4 substrate Non-substrate 0.8144 CYP450 1A2 substrate Non-inhibitor 0.9053 CYP450 2C9 inhibitor Non-inhibitor 0.9337 CYP450 2D6 inhibitor Non-inhibitor 0.9401 CYP450 2C19 inhibitor Non-inhibitor 0.9461 CYP450 3A4 inhibitor Non-inhibitor 0.9774 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9911 Ames test Non AMES toxic 0.9285 Carcinogenicity Non-carcinogens 0.5181 Biodegradation Ready biodegradable 0.9636 Rat acute toxicity 1.9204 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9596 hERG inhibition (predictor II) Non-inhibitor 0.9866
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-001l-9000000000-1db7da28c301538fe679 - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 115.22661 predictedDeepCCS 1.0 (2019) [M+H]+ 117.1888 predictedDeepCCS 1.0 (2019) [M+Na]+ 125.864746 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Blocker
- General Function
- Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216)
- Specific Function
- High voltage-gated calcium channel activity
- Gene Name
- CACNA1H
- Uniprot ID
- O95180
- Uniprot Name
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Molecular Weight
- 259160.2 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Blocker
- General Function
- Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). Channel properties are modulated by interactions with regulatory subunits (PubMed:17187064, PubMed:34997220). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:17187064, PubMed:34997220). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (PubMed:34997220)
- Specific Function
- A-type (transient outward) potassium channel activity
- Gene Name
- KCND3
- Uniprot ID
- Q9UK17
- Uniprot Name
- A-type voltage-gated potassium channel KCND3
- Molecular Weight
- 73450.53 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Yes
Neutralizer
References
- Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. [Article]
- Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. [Article]
- Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. [Article]
- Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. [Article]
- Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH
- Specific Function
- Identical protein binding
- Gene Name
- SLC4A4
- Uniprot ID
- Q9Y6R1
- Uniprot Name
- Electrogenic sodium bicarbonate cotransporter 1
- Molecular Weight
- 121459.38 Da
References
- Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [Article]
- Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [Article]
- Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [Article]
- Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404)
- Specific Function
- Monoatomic anion transmembrane transporter activity
- Gene Name
- SLC4A7
- Uniprot ID
- Q9Y6M7
- Uniprot Name
- Sodium bicarbonate cotransporter 3
- Molecular Weight
- 136042.595 Da
References
- Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [Article]
- Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [Article]
- Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [Article]
- Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)
- Specific Function
- Bicarbonate transmembrane transporter activity
- Gene Name
- SLC4A8
- Uniprot ID
- Q2Y0W8
- Uniprot Name
- Electroneutral sodium bicarbonate exchanger 1
- Molecular Weight
- 122936.66 Da
References
- Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [Article]
- Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [Article]
- Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [Article]
- Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3
- Specific Function
- Monoatomic anion transmembrane transporter activity
- Gene Name
- SLC4A5
- Uniprot ID
- Q9BY07
- Uniprot Name
- Electrogenic sodium bicarbonate cotransporter 4
- Molecular Weight
- 126254.04 Da
References
- Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [Article]
- Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [Article]
- Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [Article]
- Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)
- Specific Function
- Sodium,bicarbonate
- Gene Name
- SLC4A10
- Uniprot ID
- Q6U841
- Uniprot Name
- Sodium-driven chloride bicarbonate exchanger
- Molecular Weight
- 125945.115 Da
References
- Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [Article]
- Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [Article]
- Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [Article]
- Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [Article]
Drug created at July 08, 2007 16:59 / Updated at September 08, 2024 21:55