Sodium bicarbonate cotransporter 3

BE0004676ProteinHumansSLC4A7

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). It is acted on by 1 drug in DrugBank.

Gene name
SLC4A7
UniProtKB entry
Q9Y6M7Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,214 residues · 136,043 Da
Also known as
Bicarbonate transporter · BT · Electroneutral Na/HCO(3) cotransporter · NBC2 · NBC2B

Resolves to

Protein
UniProtQ9Y6M7UniProt nameS4A7_HUMAN
Gene
HGNCHGNC:11033NCBI Gene9497GeneCardsSLC4A7
Pharmacology
KEGGhsa:9497
Structure
PDB9OVR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium bicarbonate cotransporter 3, how selective are they, and which programs against it are still in active trials?

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