Electrogenic sodium bicarbonate cotransporter 4

BE0004677ProteinHumansSLC4A5

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. It is acted on by 1 drug in DrugBank.

Gene name
SLC4A5
UniProtKB entry
Q9BY07Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,137 residues · 126,254 Da
Also known as
NBC4 · NBCe2 · Solute carrier family 4 member 5

Resolves to

Protein
UniProtQ9BY07UniProt nameS4A5_HUMAN
Gene
HGNCHGNC:18168NCBI Gene57835GeneCardsSLC4A5
Pharmacology
KEGGhsa:57835
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Electrogenic sodium bicarbonate cotransporter 4, how selective are they, and which programs against it are still in active trials?

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