Electroneutral sodium bicarbonate exchanger 1

BE0004680ProteinHumansSLC4A8

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). It is acted on by 2 drugs in DrugBank.

Gene name
SLC4A8
UniProtKB entry
Q2Y0W8Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,093 residues · 122,937 Da
Also known as
Electroneutral Na(+)-driven Cl-HCO3 exchanger · k-NBC3 · KIAA0739 · NBC · NBC3

Resolves to

Protein
UniProtQ2Y0W8UniProt nameS4A8_HUMAN
Gene
HGNCHGNC:11034NCBI Gene9498GeneCardsSLC4A8
Pharmacology
KEGGhsa:9498
Structure
PDB5JHO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Electroneutral sodium bicarbonate exchanger 1, how selective are they, and which programs against it are still in active trials?

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