Complement C4-B

BE0004686ProteinHumansC4B

Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. It is acted on by 8 drugs in DrugBank.

Gene name
C4B
UniProtKB entry
P0C0L5Swiss-Prot
Cellular location
Secreted
Residues / weight
1,744 residues · 192,750 Da
Also known as
Basic complement C4 · C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 · CO4 · CPAMD3

Resolves to

Protein
UniProtP0C0L5UniProt nameCO4B_HUMAN
Gene
HGNCHGNC:42398NCBI Gene721GeneCardsC4B_2
Pharmacology
KEGGhsa:721
Structure
PDB6YSQPDB9U5ZPDB9U60
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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11Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement C4-B, how selective are they, and which programs against it are still in active trials?

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