Sphingosine kinase 1

BE0004728ProteinHumansSPHK1

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. It is acted on by 5 drugs in DrugBank.

Gene name
SPHK1
UniProtKB entry
Q9NYA1Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
384 residues · 42,517 Da
Also known as
2.7.1.91 · Acetyltransferase SPHK1 · SK 1 · SK1 · SPHK

Resolves to

Protein
UniProtQ9NYA1UniProt nameSPHK1_HUMAN
Gene
HGNCHGNC:11240NCBI Gene8877GeneCardsSPHK1
Pharmacology
IUPHAR/GtoPdb2204KEGGhsa:8877
Structure
PDB3VZBPDB3VZCPDB3VZD
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine kinase 1, how selective are they, and which programs against it are still in active trials?

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