Sinecatechins
Identification
- Name
- Sinecatechins
- Accession Number
- DB01266
- Description
Sinecatechins is a botanical drug product for topical use. It is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg) and some additional minor catechin derivatives i.e. Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves.
- Type
- Small Molecule
- Groups
- Approved, Investigational, Nutraceutical
- Synonyms
- Kunecatechins
- Sinecatechins
Pharmacology
- Indication
For the topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older.
- Associated Conditions
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
The mode of action of Sinecatechins (as ointment) involved in the clearance of genital and perianal warts is unknown. In vitro, sinecatechins had anti-oxidative activity; the clinical significance of this finding is unknown.
- Mechanism of action
While the exact mechanism of action of catechins is unknown, they are powerful anti-oxidants and are linked to to evidence of fighting tumors as well as enhancing immune system function.
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataVeregen Ointment 10 % Topical Paladin Labs Inc 2014-07-04 Not applicable Canada 
Veregen Ointment 150 mg/1g Topical PharmaDerm a division of Fougera Pharmaceuticals Inc. 2007-12-14 Not applicable US 
Additional Data Available- Application NumberApplication NumberAvailable for Purchase
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct CodeAvailable for Purchase
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Categories
- ATC Codes
- D06BB12 — Sinecatechins
- Drug Categories
- Classification
- Not classified
Chemical Identifiers
- UNII
- T432289GYZ
- CAS number
- 188265-33-0
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- Not Available
- External Links
- PubChem Substance
- 46506183
- 753346
- PharmGKB
- PA164749508
- Wikipedia
- Sinecatechins
- AHFS Codes
- 84:04.06 — Antivirals
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Perianal Warts / Wart, Genital 1 4 Completed Treatment Verruca, Warts 1 3 Not Yet Recruiting Treatment High-grade Anal Intraepithelial Neoplasia 1 3 Unknown Status Treatment Lamellar Ichthyosis 1 2 Not Yet Recruiting Prevention Prostate Cancer 1 2 Recruiting Treatment Arousal Disorders, Sexual / Female Sexual Arousal Disorder / Female Sexual Dysfunction (FSD) / Genito-Pelvic Pain/Penetration Disorder / Painful Intercourse / Postmenopausal Syndrome / Sexual Pain Disorders / Vestibulodynia / Vulvodynia / Vulvovaginal Atrophy 1 2, 3 Completed Treatment Basal Cell Carcinoma (BCC) 1 1 Completed Treatment External Genital Warts 1 Not Available Completed Treatment External Genital Warts 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Doak Dermatologics
- Dosage Forms
Form Route Strength Ointment Cutaneous 10 % Ointment Topical 10 % Ointment Topical 150 mg/1g - Prices
Unit description Cost Unit Veregen 15% ointment 19.86USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region Unlock Additional DataUS5795911 No 1998-08-18 2020-10-31 US US5968973 No 1999-10-19 2017-04-10 US US7858662 No 2010-12-28 2026-10-02 US US9770406 No 2017-09-26 2025-07-12 US US10434059 No 2019-10-08 2022-11-18 US Additional Data Available- Filed OnFiled OnAvailable for Purchase
The date on which a patent was filed with the relevant government.
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Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on May 16, 2007 14:06 / Updated on January 23, 2021 21:03