Sodium- and chloride-dependent GABA transporter 3

BE0004733ProteinHumansSLC6A11

Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). It is acted on by 4 drugs in DrugBank.

Gene name
SLC6A11
UniProtKB entry
P48066Swiss-Prot
Cellular location
Cell membrane
Residues / weight
632 residues · 70,605 Da
Also known as
GABT3 · GAT-3 · GAT3 · Solute carrier family 6 member 11

Resolves to

Protein
UniProtP48066UniProt nameS6A11_HUMAN
Gene
HGNCHGNC:11044NCBI Gene6538GeneCardsSLC6A11
Pharmacology
KEGGhsa:6538
Structure
PDB9CP4PDB9CP5PDB9LK7
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium- and chloride-dependent GABA transporter 3, how selective are they, and which programs against it are still in active trials?

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