Kelch-like ECH-associated protein 1

BE0004756ProteinHumansKEAP1

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). It is acted on by 11 drugs in DrugBank.

Gene name
KEAP1
UniProtKB entry
Q14145Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
624 residues · 69,666 Da
Also known as
Cytosolic inhibitor of Nrf2 · INRF2 · Kelch-like protein 19 · KIAA0132 · KLHL19

Resolves to

Protein
UniProtQ14145UniProt nameKEAP1_HUMAN
Gene
HGNCHGNC:23177NCBI Gene9817GeneCardsKEAP1
Pharmacology
IUPHAR/GtoPdb2757KEGGhsa:9817
Structure
PDB1U6DPDB1ZGKPDB2FLU
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kelch-like ECH-associated protein 1, how selective are they, and which programs against it are still in active trials?

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