Acid-sensing ion channel 3

BE0004768ProteinHumansASIC3

Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:10842183, PubMed:11587714, PubMed:9744806, PubMed:9886053). It is acted on by 2 drugs in DrugBank.

Gene name
ASIC3
UniProtKB entry
Q9UHC3Swiss-Prot
Cellular location
Cell membrane
Residues / weight
531 residues · 58,905 Da
Also known as
ACCN3 · Amiloride-sensitive cation channel 3 · ASIC3 · DRASIC · hASIC3

Resolves to

Protein
UniProtQ9UHC3UniProt nameASIC3_HUMAN
Gene
HGNCHGNC:101NCBI Gene9311GeneCardsASIC3
Pharmacology
IUPHAR/GtoPdb686KEGGhsa:9311
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acid-sensing ion channel 3, how selective are they, and which programs against it are still in active trials?

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