Y+L amino acid transporter 1

BE0004769ProteinHumansSLC7A7

Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate... It is acted on by 3 drugs in DrugBank.

Gene name
SLC7A7
UniProtKB entry
Q9UM01Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
511 residues · 55,990 Da
Also known as
Monocyte amino acid permease 2 · MOP-2 · Solute carrier family 7 member 7 · y(+)L-type amino acid transporter 1 · y+LAT-1

Resolves to

Protein
UniProtQ9UM01UniProt nameYLAT1_HUMAN
Gene
HGNCHGNC:11065NCBI Gene9056GeneCardsSLC7A7
Pharmacology
KEGGhsa:9056
Structure
PDB8XXIPDB8XYJPDB8YLP
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Y+L amino acid transporter 1, how selective are they, and which programs against it are still in active trials?

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