Fluciclovine (18F) is a radiolabelled L-leucine derivative used to image tumors, especially in the prostate. Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine.
- Mechanism
- Curator reviewed · 1 reference
Fluciclovine is transported into the prostate cancer cells via ASCT2 and LAT1 transporters. The activity of LAT1 gets increased in acidic pH, condition that is developed intra-tumorally at certain size. The uptake of fluciclovine presents an androgen-dependent dynamic in hormone sensitive cells.
- Primary indication
- Fluciclovine is indicated as a detection agent for positron emission tomography (PET) in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.Curator reviewed · 1 structured indication
- Formula / weight
- C5H8FNO2 · 132.125 g/mol (avg)
- First approval
- United States, 2016 · European Union, 2020
- Also known as
- (18F)FACBC · [18F]FACBC · 18F-Fluciclovine · Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid · FACBC F-18
- Code names
- (18F)GE-148 · anti-3-[18F]FACBC · GE-148 (18F) · GE-148 F-18 · NMK-36
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
NTEDWGYJNHZKQW-DGMDOPGDSA-NSMILESN[C@]1(C[C@H]([18F])C1)C(O)=OTransporters
What you can answer from here — as of December 02, 2025
8Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Fluciclovine (18F), and which of those have an active Phase 3 trial?
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