Carbonyl reductase [NADPH] 3

BE0004771ProteinHumansCBR3

Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). It is acted on by 4 drugs in DrugBank.

Gene name
CBR3
UniProtKB entry
O75828Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
277 residues · 30,850 Da
Also known as
1.1.1.184 · NADPH-dependent carbonyl reductase 3 · Quinone reductase CBR3 · SDR21C2 · Short chain dehydrogenase/reductase family 21C member 2

Resolves to

Protein
UniProtO75828UniProt nameCBR3_HUMAN
Gene
HGNCHGNC:1549NCBI Gene874GeneCardsCBR3
Pharmacology
KEGGhsa:874
Structure
PDB2HRB
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
6Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
9+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Carbonyl reductase [NADPH] 3, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In