Equilibrative nucleoside transporter 4

BE0004775ProteinHumansSLC29A4

Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). It is acted on by 3 drugs in DrugBank.

Gene name
SLC29A4
UniProtKB entry
Q7RTT9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
530 residues · 58,058 Da
Also known as
ENT4 · hENT4 · Plasma membrane monoamine transporter · PMAT · Solute carrier family 29 member 4

Resolves to

Protein
UniProtQ7RTT9UniProt nameS29A4_HUMAN
Gene
HGNCHGNC:23097NCBI Gene222962GeneCardsSLC29A4
Pharmacology
IUPHAR/GtoPdb1120KEGGhsa:222962
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Equilibrative nucleoside transporter 4, how selective are they, and which programs against it are still in active trials?

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